Copper‐Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes**Brian S. Daniels, Xintong Hou, Stephanie A. Corio et al.|Angewandte Chemie International Edition|2023 Abstract We describe a copper catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enantioselectivities. Enrichment of phosphorus stereocenters is also demonstrated via a Dynamic Kinetic Asymmetric Transformation (DyKAT) process. A combined experimental and theoretical mechanistic study supports an elementary step featuring insertion of a Cu I ‐phosphido into a carbon‐carbon double bond. Density functional theory calculations reveal migratory insertion as the rate‐ and stereo‐determining step, followed by a syn‐ protodemetalation.
CCDC 2154097: Experimental Crystal Structure DeterminationBrian S. Daniels, Xintong Hou, Stephanie A. Corio et al.|The Cambridge Structural Database|2023 An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
CCDC 2100976: Experimental Crystal Structure DeterminationBrian S. Daniels, Xintong Hou, Stephanie A. Corio et al.|The Cambridge Structural Database|2023 An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.