Heena Shaikh

A BSTRACT Introduction: HSP is arguably the most thoroughly studied self-antigens connected to Cardio Vascular Diseases (CVD) and periodontal disease. Hence, the major goal of this analysis was to determine the amount of HSP60 in patients’ Chronic Periodontitis (CP) patients’ serum. Materials and Methods: The current investigation involved 100 patients in all. Based on the patients’ periodontal and cardiovascular health, the patients were divided. The patients were made aware that this research had no direct bearing on disease treatment or cure. Results: In contrast to periodontal disease, which had a mean serum HSP60 of 59.94 ng/dl, CVD had a mean serum HSP60 of 85.98 ng/dl. When compared to periodontal disease, the CVD increased significantly ( P < 0.05, 0.03). Discussion and Conclusion: We emphasize the function of HSP60 in the pathophysiology of individuals with chronic periodontitis based on the findings of the current investigation. Serum HSP60 concentrations can serve as a biomarker for periodontal inflammation. More longitudinal and interventional research with a larger sample size is required to validate the present findings. In periodontal therapies, targeting HSP60 may enhance results.

Aim: This research aimed to investigate the occurrence and trends of non-alcoholic fatty liver disease (NAFLD) in individuals diagnosed with type 2 diabetes mellitus. Material and Methods: During the course of the study, a total of 100 patients with a diagnosis of type 2 diabetes mellitus were enrolled by researchers, adhering to defined inclusion and exclusion criteria. The diagnosis of NAFLD was confirmed via ultrasonography, which revealed a bright liver appearance. Results: The ultrasonography analysis revealed that 50% of the patients were diagnosed with fatty liver, leading to their classification in group A. The remaining patients, who exhibited no signs of fatty liver, were assigned to Group B. Group A exhibited significantly higher levels of serum AST, serum ALT, and serum alkaline phosphatase in comparison to Group B. Group B showed an elevated Serum AST/ALT ratio when compared to group A. Conclusion: The rising rates of obesity are increasingly linked to a surge in conditions such as type 2 diabetes mellitus and non-alcoholic fatty liver disease, has rendered the management of these patients more complex than ever. Clinicians must recognize the extrahepatic manifestations associated with NAFLD, as early identification of T2DM is crucial for effectively managing these patients.

Aim: This study primarily focused on evaluating the triglyceride-glucose (TyG) index in patients experiencing erectile dysfunction (ED) and examining its potential role as a predictive tool in diagnosing ED. Materials and Methods: The study involved a cohort of 50 patients diagnosed with erectile dysfunction, forming the study group, alongside 50 individuals exhibiting normal sexual function, who served as the control group. The assessment of erectile function was conducted using the International Index of Erectile Function-5 (IIEF-5) questionnaire. All participants underwent the calculation of the TyG index. Results: The examination indicated that there were no notable disparities between the two groups regarding smoking rates, alcohol intake, or measurements of high-density lipoprotein cholesterol, haemoglobin, creatinine levels, and leukocyte and platelet counts. Individuals experiencing erectile dysfunction were found to be older and exhibited significantly higher levels of total cholesterol, low-density lipoprotein cholesterol, glucose, triglycerides, and the TyG index compared to the control group. Conclusion: I n patients with erectile dysfunction, the TyG index-a simple test for insulin resistance (IR) -was found to be predictive.

There has been a noticeable increase in the use of alternative strategies such as herbal medicines and laser therapies to tackle a range of health issues, including oral diseases. Therefore, it is of interest to examine how synbiotics affect tooth extraction socket healing and problems. Hence, a total of 210 patients, were split into three groups of 70 individuals each. The primary outcome measures were assessed on the 3rd, 5th, and 7th days after the extraction. Group 3 patients had the highest incidence of bleeding, while group 1 had the lowest. Group 3 experienced the highest level of discomfort and swelling, while group 1 reported the lowest. Thus, post-extraction wound healing using synbiotics' benefits.

Background: Cardiovascular diseases (CVDs), especially ST-Elevation Myocardial Infarction (STEMI), represent a critical public health challenge in India, contributing significantly to premature mortality. In resource-constrained settings like the Jammu Division, delays in diagnosis and limited access to timely care exacerbate the problem. The average delay from symptom onset to treatment exceeds 360 minutes, far beyond the recommended 60-minute window, resulting in avoidable fatalities. Objective: This pilot study aimed to evaluate the effectiveness of Tricog’s InstaECG solution in enabling rapid, AI-assisted ECG interpretation and streamlined care pathways to improve STEMI detection and response in semi-urban and rural public health facilities across the Jammu Division. Methodology: Approved by the Directorate of Health Services, Jammu Division, the pilot was implemented between January 11 and April 26, 2023, across four government health facilities in Jammu and Samba districts. The intervention included deploying AI-enabled ECG machines, real-time cloud-based data transmission, and mobile app-based feedback to physicians. Pre-implementation diagnostics, training for health staff, and appointment of STEMI coordinators ensured smooth execution. Outcomes: Screening Reach: 2,080 patients screened post-implementation, a significant scale-up from 262 during the baseline phase. STEMI Detection Rate: Increased from 0.3% to 1.8%, reflecting an 85.7% improvement. Diagnosis Turnaround Time: Reduced from 73 minutes to just 4 minutes, a 94.5% reduction. Timely Intervention: Thrombolysis was initiated in STEMI patients within an average of 26 minutes post-ECG, well within the golden hour. Clinical Outcomes: Among 23 critical STEMI patients referred to a tertiary center, 21 survived—reflecting a 5% mortality rate, notably better than the national average. System Strengthening: Real-time analytics, integrated care protocols, and digital triaging demonstrated scalable and replicable improvements. Conclusion: The Jammu STEMI Pilot successfully demonstrated that AI-powered, technology-enabled diagnostic systems can revolutionize acute cardiac care delivery in low-resource public health settings. By drastically reducing diagnostic delays and ensuring structured treatment pathways, the pilot not only improved patient outcomes but also established a replicable model for broader implementation across similar geographies. The findings support the scale-up of Tricog’s InstaECG solution under state and national health missions, particularly in Tier 2 and Tier 3 regions, to bridge the urban-rural cardiac care divide and reduce CVD-related mortality.