Cited by 4.5kOpen Access
The University of Texas MD Anderson Cancer Center
Publishes on Angiogenesis and VEGF in Cancer, Lung Cancer Treatments and Mutations, Cancer, Hypoxia, and Metabolism. 131 papers and 16.4k citations.
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Antithrombin, a member of the serpin family, functions as an inhibitor of thrombin and other enzymes. Cleavage of the carboxyl-terminal loop of antithrombin induces a conformational change in the molecule. Here it is shown that the cleaved conformation of antithrombin has potent antiangiogenic and antitumor activity in mouse models. The latent form of intact antithrombin, which is similar in conformation to the cleaved molecule, also inhibited angiogenesis and tumor growth. These data provide further evidence that the clotting and fibrinolytic pathways are directly involved in the regulation of angiogenesis.