Cited by 133
University of Freiburg
Publishes on Neuropeptides and Animal Physiology, Receptor Mechanisms and Signaling, Epilepsy research and treatment. 37 papers and 727 citations.
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Marked elevations of urinary adenosine 3',5'-monophosphate occurred on the day of rapid switch from a depressed into a manic state in patients with manic-depressive illness. It is suggested that this increase might serve a trigger function for the process by which catecholamines are elevated during the manic phase of the illness.
Adenosine 3',5'-monophosphate (cyclic AMP) was measured in lumbar spinal fluid of 41 patients with peripheral or central nervous system (CNS) disease. Cyclic AMP levels appeared unrelated to age, sex, or time of day that samples were obtained. Levels in patients with Parkinson's disease did not differ significantly from those in patients with familial or acquired dyskinesias, spinocerebellar disorders, or from those in patients free of CNS disease. Neither acute nor chronic administration of levodopa altered cyclic AMP concentrations. In contrast, probenecid caused a substantial rise in levels of this nucleotide. Results suggest that cyclic AMP efflux from the spinal fluid compartment may be mediated by a probenecid-sensitive transport system and that use of probenecid may provide a means for studying drug or disease effects on the central turnover of cyclic AMP in man.