University of Southern California
Publishes on Renal Transplantation Outcomes and Treatments, Organ Transplantation Techniques and Outcomes, T-cell and B-cell Immunology. 170 papers and 10.7k citations.
Add your photo, update your bio, and get notified when your ranking changes.
Several methods of estimating error rates in Discriminant Analysis are evaluated by sampling methods. Multivariate normal samples are generated on a computer which have various true probabilities of misclassification for different combinations of sample sizes and different numbers of parameters. The two methods in most common use are found to be significantly poorer than some new methods that are proposed.
The microdroplet lymphocyte cytotoxicity test was examined thoroughly in an effort to increase the reproducibility of the test. The discrepancy rate in a large series of tests was reduced from 5.16% at the start of this study to the present 0.95% by introducing certain modifications in the technique. Variables connected with the isolation of lymphocytes, handling of antisera, quality of antisera, amount of complement, incubation temperature, duration of incubation, fixing of reactions, and reading of reactions were studied. The method which has resulted appears to be reproducible, simple, and readily usable on a large scale.
Several methods of estimating error rates in Discriminant Analysis are evaluated by sampling methods. Multivariate normal samples are generated on a computer which have various true probabilities of misclassification for different combinations of sample sizes and different numbers of parameters. The two methods in most common use are found to be significantly poorer than some new methods that are proposed.
Summary Cultured tumor cells from 7 established lines and 12 short-term cultures were reacted with lymphocytes from patients with the same “histological type” of cancer as the target cells in 995 tests and with lymphocytes from normal controls in 1099 tests. The average reactivity was significantly greater with lymphocytes from normal persons in 3 of the 7 established lines and 2 of 12 short-term cultures. In only 1 short-term bladder tumor culture was there indication of greater cytotoxicity produced by lymphocytes from bladder cancer patients than by cells from normal persons. Cell-mediated target cell reduction of cultured human tumor cells is not confined to patients with cancer.