T. Shimomura

Tyrosine kinase inhibitors (TKIs) have been shown to affect glucose metabolism in patients with chronic myeloid leukemia (CML); however, their precise mechanism of action remains unknown. We herein report the case of a 57-year-old diabetic CML patient who was resistant to imatinib and initially required 20 units of insulin daily to control his blood glucose levels. After the initiation of dasatinib, the patient's insulin requirements declined rapidly and insulin treatment was discontinued within two weeks. Meanwhile, the fasting C-peptide immunoreactivity increased two-fold, suggesting that dasatinib facilitated the recovery of insulin production. Dasatinib may therefore be beneficial for diabetic CML patients, especially those who require insulin treatment.

6.5-wt.% SiFe filaments having almost zero magnetostriction were obtained using an in-rotating-water-spinning method. It was found that the filament diameter and the structure of as-cast filaments are affected by processing conditions such as spinneret diameter and throughput. In the case of filaments with diameters less than about 90 mu m, the primary dendrite arms oriented toward the direction of the filament length can be observed in place of the polycrystalline structure. High-temperature heat treatment causes the filaments with the oriented dendrite structure to change to the single-crystalline structure. The single-crystalline structure filaments were found to have superb ductility and excellent magnetic properties such as rectangular hysteresis loop with large Barkhausen effect, low coercive force, and high saturation magnetic flux density in the case of DC magnetization. The discontinuous motion of the magnetic domain wall was also observed for the single-crystalline filaments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>