Klaus Bock

Proton decoupled and undecoupled 13C n.m.r. spectra have been measured on a number of hexopyranoses. The direct coupling constants between the anomeric carbon atoms and protons {1J[13C–H(1)]} were found to be ca. 160 in the β-anomers and ca. 170 Hz in the α-anomers; the difference of ca. 10 Hz between pairs of anomers was found in almost all cases. Chemical shifts and 1J(13CH) values of the other carbon atoms in the pyranose rings were also measured.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbohydrate Structural Determination by NMR Spectroscopy: Modern Methods and Limitations†Jens Ø. Duus, Charlotte H. Gotfredsen, and Klaus BockView Author Information Carlsberg Laboratory, Department of Chemistry, Gamle Carlsberg Vej 10, DK-2500 Valby Copenhagen, Denmark Cite this: Chem. Rev. 2000, 100, 12, 4589–4614Publication Date (Web):November 15, 2000Publication History Received17 July 2000Published online15 November 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/cr990302nhttps://doi.org/10.1021/cr990302nresearch-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views14790Altmetric-Citations606LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbohydrates,Chemical structure,Nuclear magnetic resonance spectroscopy,Oligosaccharides,Probes Get e-Alerts

Nuclear magnetic resonance properties are shown to be in good accord with those that are expected for synthetic oligosaccharides in the conformations which are predicted by hard-sphere molecular modelling and taking into consideration the important contribution by the exo-anomeric effect. The studies involve first a comparison of the β D Gal(1 → 3)β D GlcNAc (Type 1) and β D Gal(1 → 4)β D GlcNAc (Type 2) disaccharide structures based mainly on 13 Cmr and then an examination of the relationships between the calculated conformations and 1 Hmr and 13 Cmr parameters for human blood group determinants which are derived from the Type 1 core disaccharide. Among the structures examined are the di-, tri-, and tetrasaccharides for the ABH and Lewis antigenic determinants. Certain immunological–conformational relationships are noted.