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Dawn C. Lever

Memorial Sloan Kettering Cancer Center

Publishes on Bacterial Genetics and Biotechnology, RNA and protein synthesis mechanisms, Bacteriophages and microbial interactions. 1 papers and 57 citations.

1Publications
57Total Citations
Bacterial Genetics and BiotechnologyRNA and protein synthesis mechanismsBacteriophages and microbial interactions

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Top publicationsby citations

A novel host factor for integration of mycobacteriophage L5
Marisa L. Pedulla, Mong Hong Lee, Dawn C. Lever et al.|Proceedings of the National Academy of Sciences|1996
Cited by 57Open Access

Bacterial integration host factors (IHFs) play central roles in the cellular processes of recombination, DNA replication, transcription, and bacterial pathogenesis. We describe here a novel mycobacterial IHF (mIHF) of Mycobacterium smegmatis and Mycobacterium tuberculosis that stimulates integration of mycobacteriophage L5. mIHF is the product of a single gene and is unrelated at the sequence level to other integration host factors. By itself, mIHF does not bind preferentially to attP DNA, although it significantly alters the pattern of integrase (Int) binding, promoting the formation of specific integrase-mIHF-attP intasome complexes.