Michael Lever, Peter Sizeland, Lois M. Bason et al.|Biochimica et Biophysica Acta (BBA) - General Subjects|1994
Cited by 113
Waikato Hospital
Publishes on Metabolism and Genetic Disorders, Renal Diseases and Glomerulopathies, Renal function and acid-base balance. 16 papers and 834 citations.
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The renin-angiotensin system has been shown to have an effect on erythropoietin synthesis and hemoglobin concentration. We present a retrospective study of stable renal transplant recipients who received an angiotensin-converting enzyme (ACE) inhibitor as treatment of hypertension. Fifteen patients were eligible, with a mean hemoglobin concentration of 130.7 +/- 22.7 g/L (SD). Within 6 months of ACE-inhibitor therapy, the mean hemoglobin had fallen significantly to 110.5 +/- 23.2 g/L (p less than 0.001). No parallel change in leukocyte or platelet counts was evident. Prospective studies are needed to clarify the effect of inhibition of the renin-angiotensin system on erythropoietin synthesis and release.