Cited by 348
University of Freiburg
Publishes on Neurogenesis and neuroplasticity mechanisms, Nerve injury and regeneration, Fetal and Pediatric Neurological Disorders. 164 papers and 5k citations.
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Journal Article Myelin Formation in the Sciatic Nerve of the Rat: A Quantitative Electron Microscopic, Histochemical and Radioautographic Study Get access R. L. Friede, M.D., R. L. Friede, M.D. Cleveland, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Samorajski, Ph.D. T. Samorajski, Ph.D. Cleveland, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Neuropathology & Experimental Neurology, Volume 27, Issue 4, October 1968, Pages 546–570, https://doi.org/10.1097/00005072-196810000-00002 Published: 01 October 1968
A method for the in situ fixation of human meninges for electron microscopic examination is described. It was found that the cranial meninges of humans do not include a subdural space. Instead there is a complex, tight layer of cells, the interface layer, composed in the innermost portion of the dura mater (the dural border cells) and the outermost portion of the arachnoid (the arachnoid barrier layer). The fusion of these components within the interface layer is much more intimate than is either the attachment of the dural border cells to the dura proper or that of the arachnoid barrier layer to the rest of the arachnoid. The fine structural characteristics of these layers are defined. The erroneous macroscopic impression of a subdural space results from an extraordinary lack of cohesion within the dura-arachnoid interface layer conditioned by a) a complete absence of a collagenous reinforcement within this zone, b) the presence of large extracellular cisterns between the dural border cells, and c) a paucity of intercellular contacts within that latter layer. An understanding of the fine structural organization of the interface layer is essential to any consideration of the pathogenesis of subdural lesions: these form within a sheet of torn dural border cells and not within a preexistent tissue compartment.
Electron microscopic data on human bridging veins show thin walls of variable thickness, circumferential arrangement of collagen fibres and a lack of outer reinforcement by arachnoid trabecules, all contributory to the subdural portion of the vein being more fragile than its subarachnoid portion. These features explain the laceration of veins and the subdural location of resultant haematomas.