Oral magnesium supplementation reduces insulin resistance in non‐diabetic subjects – a double‐blind, placebo‐controlled, randomized trialFrank C. Mooren, Karsten Krüger, Klaus Völker et al.|Diabetes Obesity and Metabolism|2010 The incidence of insulin resistance and metabolic syndrome correlates with the availability of magnesium (Mg). We studied the effect of oral Mg supplementation on insulin sensitivity and other characteristics of the metabolic syndrome in normomagnesemic, overweight, insulin resistant, non-diabetic subjects. Subjects were tested for eligibility using oral glucose tolerance test (OGTT) and subsequently randomized to receive either Mg-aspartate-hydrochloride (n = 27) or placebo (n = 25) for 6 months. As trial endpoints, several indices of insulin sensitivity, plasma glucose, serum insulin, blood pressure and lipid profile were determined. Mg supplementation resulted in a significant improvement of fasting plasma glucose and some insulin sensitivity indices (ISIs) compared to placebo. Blood pressure and lipid profile did not show significant changes. The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes.
Intraerythrocytic Crystals in a White Patient with Hemoglobin C in the Absence of Other Types of HemoglobinAbstract Tetragonal crystals of hemoglobin were observed in approximately 2 per cent of erythrocytes of a sixteen-year-old white male of Italian parentage, who had hemoglobin C in the absence of A, S, and F. The clinical and hematological features of the patient described are similar to those with "pure" hemoglobin C disease reported by others. The essential features are: chronic anemia of a mild degree, congestive splenomegaly, evidences of increased red cell destruction, hyperplastic marrow with increased numbers of immature erythrocytes in the peripheral blood, target cells and increased erythrocyte resistance to hyptonic saline solutions. Electrophoretic analysis of hemolysates of both parents, one brother and a maternal uncle revealed hemoglobin A and C. The hemolysate of one sister revealed only hemoglobin A. None of the relatives examined had hemoglobin S or F and none showed hematologic abnormalities.
Lactic Acid Dehydrogenase Activity and Plasma Hemoglobin Elevations in Sickle Cell DiseaseCherry Neely, Takeshi Wajima, A. Kraus et al.|American Journal of Clinical Pathology|1969 Journal Article Lactic Acid Dehydrogenase Activity and Plasma Hemoglobin Elevations in Sickle Cell Disease Get access C. L. Neely, M.D., C. L. Neely, M.D. Section of Hematology, University of Tennessee College of Medicine, Memphis, Tennessee 38103 Search for other works by this author on: Oxford Academic Google Scholar T. Wajima, M.D., T. Wajima, M.D. Section of Hematology, University of Tennessee College of Medicine, Memphis, Tennessee 38103 Search for other works by this author on: Oxford Academic Google Scholar A. P. Kraus, M.D., A. P. Kraus, M.D. Section of Hematology, University of Tennessee College of Medicine, Memphis, Tennessee 38103 Search for other works by this author on: Oxford Academic Google Scholar L. W. Diggs, M.D., L. W. Diggs, M.D. Section of Hematology, University of Tennessee College of Medicine, Memphis, Tennessee 38103 Search for other works by this author on: Oxford Academic Google Scholar L. Barreras, M.D. L. Barreras, M.D. Section of Hematology, University of Tennessee College of Medicine, Memphis, Tennessee 38103 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 52, Issue 2, 1 August 1969, Pages 167–169, https://doi.org/10.1093/ajcp/52.2.167 Published: 01 August 1969 Article history Received: 23 December 1968 Published: 01 August 1969