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B. Muñoz

Universidad Complutense de Madrid

Publishes on Mollusks and Parasites Studies, Wildlife Ecology and Conservation, Parasite Biology and Host Interactions. 27 papers and 1.1k citations.

27Publications
1.1kTotal Citations

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Top publicationsby citations

MCM-41 Organic Modification as Drug Delivery Rate Regulator
B. Muñoz, A. Rámila, Joaquı́n Pérez-Pariente et al.|Chemistry of Materials|2002
Cited by 615

Organic modification with aminopropyl group of two MCM-41 materials having different pore sizes (obtained from trimethylalkylammonium surfactants with different chain sizes (16 and 12 carbon atoms)) has been carried out in order to control the delivery rate of ibuprofen from the siliceous matrix. This functionalization was performed by two different methods: the as-synthesized MCM-41 sample was treated with aminopropyltrimethoxysilane (method a), and the MCM-41 was first calcined and then funtionalized by reaction with aminopropyltrimethoxysilane (method b). The amount of ibuprofen adsorbed from hexane solution is lower for the C12 derived materials. A slower delivery rate has been observed for method b, whereas a minor influence of the pore size on the delivery rate has been found.

Bioactive glasses as accelerators of apatite bioactivity
María Vallet‐Regí, A. Rámila, S. Padilla et al.|Journal of Biomedical Materials Research Part A|2003
Cited by 41

Synthetic carbonatehydroxyapatite is the ceramic closest to the mineral component of human bone and seems, therefore, the optimum material to use in osseous implants. However, in vitro assays performed to determine its bioactivity have shown no positive results after 2 months of assay. With the aim of improving this bioactivity, a new biphasic material was synthesized composed mainly of synthetic carbonatehydroxyapatite and only 5% of a sol-gel bioactive glass. In vitro assays were assessed to determine the bioactive behavior of this new material and revealed that the addition of a minimal amount of bioactive glass is enough to induce bioactivity on synthetic carbonatehydroxyapatites.