Huiyong Yin

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFree Radical Lipid Peroxidation: Mechanisms and AnalysisHuiyong Yin†‡, Libin Xu†, and Ned A. Porter*†View Author Information† Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States‡ Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt School of Medicine, Nashville, Tennessee 37232, United StatesE-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 10, 5944–5972Publication Date (Web):August 23, 2011Publication History Received18 March 2011Published online23 August 2011Published inissue 12 October 2011https://pubs.acs.org/doi/10.1021/cr200084zhttps://doi.org/10.1021/cr200084zreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views20137Altmetric-Citations1255LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Free radicals,Lipids,Oxidation,Oxides,Oxygen Get e-Alerts

Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipid cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE.