Matthew Frank

BACKGROUND: The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy, especially the risk of T-cell neoplasms related to viral vector integration, is an emerging concern. METHODS: We reviewed our clinical experience with adoptive cellular CAR T-cell therapy at our institution since 2016 and ascertained the occurrence of second tumors. In one case of secondary T-cell lymphoma, a broad array of molecular, genetic, and cellular techniques were used to interrogate the tumor, the CAR T cells, and the normal hematopoietic cells in the patient. RESULTS: mutant clonal hematopoiesis. No evidence of oncogenic retroviral integration was found with the use of multiple techniques. CONCLUSIONS: Our results highlight the rarity of second tumors and provide a framework for defining clonal relationships and viral vector monitoring. (Funded by the National Cancer Institute and others.).

Abbreviations Introduction 1. Frankfurt-on-Wye/Monmouth an der Oder: Population transfer before the Second World War 2. 'Not a Difference of Principle, but a Difference of Emphasis': Wartime studies on population transfer, 1940-45 3. From Prague to Potsdam: Expulsions from Czechoslovakia and Poland, May-July 1945 4. 'In Germany Now': The German Refugee Crisis, July-October 1945 5. 'A Thankless Task': Official responses to the expulsions, August-December 1945 6. Crisis! What Crisis?: German refugee rumours and scares, October 1945-January 1946 7. 'Useless Mouths': Transfer of the Germans from Czechoslovakia and Poland, 1946-47 Conclusion Bibliography Index

This special issue examines how refugees and refugee crises were defined and managed by European nation-states in the four decades after the end of the First World War. Our introduction sketches out the broad historical canvas of the refugee problem in Europe and highlights a number of overarching themes of and comparisons between the papers.

Journal of Refugee Studies new materials from recently opened soviet archives are presented by a number of Russian scholars, and help illuminate political and diplomatic hidtory of immediate post war world the book is of greatest interest in revealing products of limited culture contact between residual ethnic groupings present in Russian and Anglophone academia: a fleeting exchange of ideas across a set of prevailing intellectual differences. - Slavic Review