Xia Li

Impaired glucose regulation (IGR) is the prestate of diabetes; about 1/3 of IGR patients will develop to diabetes finally. In this study, we investigated the serum tumor necrosis factor-alpha (TNF- α ) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose regulation (IGR). A total of 70 IGR patients received the conventional nerve conduction test, including 30 patients with peripheral neuropathy (PN) and 40 patients without peripheral neuropathy (NPN). The other 40 healthy individuals were recruited as controls. The serum TNF- α and IL-6 in IGR patients were higher than in control group, and serum TNF- α and IL-6 levels in IGR-PN group were higher than in IGR-NPN group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">27.7</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">17.8</mml:mn></mml:math> versus <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mn fontstyle="italic">1</mml:mn><mml:mn fontstyle="italic">3.1</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">6.7</mml:mn></mml:math> pg/mL and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mn fontstyle="italic">18.1</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">17.7</mml:mn></mml:math> versus <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mn fontstyle="italic">6.4</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">3.7</mml:mn></mml:math> pg/mL, resp., both <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M5"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0.0</mml:mn><mml:mn fontstyle="italic">5</mml:mn></mml:math>). Multifactors logistic regression analysis showed that TNF- α (OR = 0.893; <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M6"><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">0.00</mml:mn><mml:mn fontstyle="italic">9</mml:mn></mml:math>) was an independent factor affecting whether IGR could combine with peripheral neuropathy. TNF- α and IL-6 could aggregate peripheral neuropathy in impaired glucose regulation patients; TNF- α might be independent risk factor for peripheral neuropathy in glucose regulation impaired patients.

In light of the severity of coronavirus disease (COVID-19) around the world, it is an arduous task for China to prevent COVID-19 from being imported from abroad and proliferating domestically. The community is the first and most effective line of defense and can effectively cut off the channels of spread of the epidemic. In order to reduce risks of COVID-19 transmission in the community, it is necessary to sort out the loopholes in risk and management, as well as investigate previous epidemic transmission events in the community.

China Academy of Chinese Medical Sciences. An erratum was issued for: In Vivo Calcium Imaging of Dorsal Root Ganglia Neurons' Response to Somatic and Visceral Stimuli. The Authors section was updated.

Objective: To investigate the pathological change of endometrium and the related factors in postoperative breast cancer patients receiving tamoxifen therapy. Methods: Eighty-two postoperative breast cancer patients receiving tamoxifen therapy, who were admitted to gynecologic ward of Hebei Medical University Forth Hospital from July 1, 2008 to December 31, 2009 due to their gynecologic problems, were collected, and their clinicopathological information were anaylzed retrospectively. Results: Of 82 patients, 74 were followed-up, 4 were lost, and 4 were dead. The types of endometrial pathology of patients receiving tamoxifen included endometrial polypoid hyperplasia (n = 16, 21.6%), endometrial polyps (n = 14, 18.9%), adenomyoma (n = 11, 14.9%), atypical hyperplasia (n = 4, 5.4%) and endometrial carcinoma (n = 9, 12.2%). The related factors analysis revealed that endometrial diseases were positively associated with menopause, which meant that the postmenopausal patients were more likely to suffer from endometrial cancer. Moreover, there was a positive correlation between the duration of tamoxifen use and endometrial cancer, especially for the patients receiving tamoxifen for 5 years or more. The endometrial thickness by B-ultrasonic examination was also positively correlated with endometrial cancer. Conclusion: Tamoxifen therapy in postoperative breast cancer patients can lead to endometrial diseases. Postmenopausal patients and the patients receiving tamoxifen for 5 years or more are more likely to develop endometrial cancer. Combination of B-ultrasonic examination and hysteroscopy is an effective way to find endometrial lesions induced by tamoxifen therapy. DOI:10.3781/j.issn.1000-7431.2013.07.010