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Lei Wang

Hebei Medical University

ORCID: 0000-0002-7584-8802

Publishes on Membrane Separation Technologies, Membrane-based Ion Separation Techniques, Extraction and Separation Processes. 460 papers and 9.9k citations.

460Publications
9.9kTotal Citations

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Top publicationsby citations

Ion sieving by a two-dimensional Ti3C2Tx alginate lamellar membrane with stable interlayer spacing
Jin Wang, Zhijie Zhang, Jiani Zhu et al.|Nature Communications|2020
Cited by 305Open Access

Abstract Two-dimensional membranes attract extensive interest due to the anomalous transport phenomena; however, the ion separation performance is below the theoretical prediction. The stabilization of d-spacing is a key step for enhancing ion selectivity. Here, we demonstrate a strategy for stabilizing the Ti 3 C 2 T x laminar architecture by alginate hydrogel pillars. After pillared by Ca-alginate, the nanochannel diameters are effectively fixed at 7.4 ± 0.2 Å, and the membrane presents a permeation cutoff and an outstanding sieving property towards valent cations. When applied for acid recovery, the outstanding H + /Fe 2+ selectivity makes the membrane a promising substitution for traditional ion-exchange membranes. Moreover, the ultrathin Mn-alginate pillared membrane with identical d-spacing exhibits 100% Na 2 SO 4 rejection with high water permeance, which is superior to the state-of-the-art nanofiltration membranes. Building on these findings, we demonstrate an efficient method to tune the ion selectivity and introduce a new perspective for energy- and environment-related applications.

A study on the association between infectious burden and <scp>A</scp>lzheimer's disease
Xian‐Le Bu, Xiaojuan Yao, S.‐S. Jiao et al.|European Journal of Neurology|2014
Cited by 272

BACKGROUND AND PURPOSE: Previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases and stroke. In the present study, the association between infectious burden (IB) and Alzheimer's disease (AD) was examined. METHODS: Antibody titers to common infectious pathogens including cytomegalovirus (CMV), herpes simplex virus type 1 (HSV-1), Borrelia burgdorferi, Chlamydophila pneumoniae and Helicobacter pylori were measured by enzyme-linked immunosorbent assay in 128 AD patients and 135 healthy controls. IB was defined as a composite serological measure of exposure to these common pathogens. RESULTS: Seropositivities toward zero-two, three and four-five of these pathogens were found in 44%, 40% and 16% of healthy controls but in 20%, 44% and 36% of AD patients, respectively. IB, bacterial burden and viral burden were independently associated with AD after adjusting for age, gender, education, APOE genotype and various comorbidities. Mini-Mental State Examination scores were negatively correlated with IB in all cases. Serum beta-amyloid protein (Aβ) levels (i.e. Aβ40, Aβ42 and total Aβ) and inflammatory cytokines (i.e. interferon-γ, tumor necrosis factor α, interleukin-1β and interleukin-6) in individuals exposed to four-five infectious pathogens were significantly higher than those exposed to zero-two or three pathogens. CONCLUSIONS: IB consisting of CMV, HSV-1, B. burgdorferi, C. pneumoniae and H. pylori is associated with AD. This study supports the role of infection/inflammation in the etiopathogenesis of AD.