Hua Zhang

BACKGROUND: Fish consumption is considered the primary pathway of methylmercury (MeHg) exposure for most people in the world. However, in the inland regions of China, most of the residents eat little fish, but they live in areas where a significant amount of mercury (Hg) is present in the environment. OBJECTIVES: We assessed concentrations of total Hg and MeHg in samples of water, air, agricultural products, and other exposure media to determine the main exposure pathway of Hg in populations in inland China. METHODS: We selected Guizhou Province for our study because it is highly contaminated with Hg and therefore is representative of other Hg-contaminated areas in China. We selected four study locations in Guizhou Province: three that represent typical environments with severe Hg pollution [due to Hg mining and smelting (Wanshan), traditional zinc smelting (recently closed; Weining), and heavy coal-based industry (Qingzhen)], and a village in a remote nature reserve (Leigong). RESULTS: The probable daily intake (PDI) of MeHg for an adult population based on 60 kg body weight (bw) was considerably higher in Wanshan than in the other three locations. With an average PDI of 0.096 microg/kg bw/day (range, 0.015-0.45 microg/kg bw/day), approximately 34% of the inhabitants in Wanshan exceeded the reference dose of 0.1 microg/kg bw/day established by the U.S. Environmental Protection Agency. The PDI of MeHg for residents in the three other locations were all well below 0.1 microg/kg bw/day (averages from 0.017 to 0.023 microg/kg bw/day, with a maximum of 0.095 microg/kg bw/day). In all four areas, rice consumption accounted for 94-96% of the PDI of MeHg. CONCLUSION: We found that rice consumption is by far the most important MeHg exposure route; however, most of the residents (except those in Hg-mining areas) have low PDIs of MeHg.

Modern humans have occupied almost all possible environments globally since exiting Africa about 100,000 years ago. Both behavioral and biological adaptations have contributed to their success in surviving the rigors of climatic extremes, including cold, strong ultraviolet radiation, and high altitude. Among these environmental stresses, high-altitude hypoxia is the only condition in which traditional technology is incapable of mediating its effects. Inhabiting at >3,000-m high plateau, the Tibetan population provides a widely studied example of high-altitude adaptation. Yet, the genetic mechanisms underpinning long-term survival in this environmental extreme remain unknown. We performed an analysis of genome-wide sequence variations in Tibetans. In combination with the reported data, we identified strong signals of selective sweep in two hypoxia-related genes, EPAS1 and EGLN1. For these two genes, Tibetans show unusually high divergence from the non-Tibetan lowlanders (Han Chinese and Japanese) and possess high frequencies of many linked sequence variations as reflected by the Tibetan-specific haplotypes. Further analysis in seven Tibetan populations (1,334 individuals) indicates the prevalence of selective sweep across the Himalayan region. The observed indicators of natural selection on EPAS1 and EGLN1 suggest that during the long-term occupation of high-altitude areas, the functional sequence variations for acquiring biological adaptation to high-altitude hypoxia have been enriched in Tibetan populations.

Over the past 20 years, China has experienced a steady decline in bicycle use. To address this trend, China's central and local government for urban transportation created Public Transit Priority to encourage public transport initiatives. As part of this effort, the government of the city of Hangzhou launched Hangzhou Public Bicycle in 2008. This service allows members to access a shared fleet of bicycles. As of March 2011, Hangzhou Public Bicycle operated 60,600 bicycles with 2,416 fixed stations in eight core districts. To understand factors leading to bikesharing adoption and barriers to adoption, the authors conducted an intercept survey in Hangzhou between January and March 2010. Two separate questionnaires were issued to bikesharing members and nonmembers to identify key differences and similarities between these groups. In total, 806 surveys were completed by 666 members and 140 nonmembers. The authors found that bikesharing was capturing modal share from bus transit, walking, autos, and taxis. Approximately 30% of members had incorporated bikesharing into their most common commute. Members indicated that they most frequently used a bikesharing station closest to either home (40%) or work (40%). These modal shifts suggested that bikesharing acted as both a competitor and a complement to existing public transit. Members exhibited a higher rate of auto ownership than nonmembers. This finding suggested that bikesharing was attractive to car owners. Recommendations for improving bikesharing in Hangzhou included adding stations and real-time bike and parking availability technologies, improving bike maintenance and locking mechanisms, and extending operational hours.

Mercury (Hg) bioaccumulation in aquatic food webs has been much studied, motivated from high Hg levels found in many fish species important for human consumption. Hg bioaccumulation in terrestrial food chains have received little attention and assumed to be of minor importance. However, recent studies showed that rice can be an important pathway of methylmercury (MeHg) exposure to inhabitants in Hg mining areas in China. In this study, 59 sampling sites (including 32 sites from "heavily polluted area", 19 from "less-impacted area" and 8 from "control sites") were selected in a Hg mining area in China and both inorganic Hg (IHg) and MeHg were determined in rice grain (brown rice) and soil samples to evaluate Hg bioaccumulation in rice grain. Bio-Accumulation Factors (BAFs) for IHg ranged from 0.00014 to 0.51 and from 0.71 to 50 for MeHg. BAFs for MeHg were on average more than 800 times higher than those for IHg (maximum: 40,000 times). This study, for the first time, showed that rice grain is an intensive bioaccumulator of MeHg, but not of IHg, which may be trapped by the roots.