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Yuval Sedan

Hebrew University of Jerusalem

Publishes on Protein Structure and Dynamics, Mass Spectrometry Techniques and Applications, Chemical Synthesis and Analysis. 2 papers and 1k citations.

2Publications
1kTotal Citations
Protein Structure and DynamicsMass Spectrometry Techniques and ApplicationsChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies ResearchEnzyme Structure and Function

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Top publicationsby citations

Peptiderive server: derive peptide inhibitors from protein–protein interactions
Yuval Sedan, Orly Marcu, Sergey Lyskov et al.|Nucleic Acids Research|2016
Cited by 110Open Access

The Rosetta Peptiderive protocol identifies, in a given structure of a protein-protein interaction, the linear polypeptide segment suggested to contribute most to binding energy. Interactions that feature a 'hot segment', a linear peptide with significant binding energy compared to that of the complex, may be amenable for inhibition and the peptide sequence and structure derived from the interaction provide a starting point for rational drug design. Here we present a web server for Peptiderive, which is incorporated within the ROSIE web interface for Rosetta protocols. A new feature of the protocol also evaluates whether derived peptides are good candidates for cyclization. Fast computation times and clear visualization allow users to quickly assess the interaction of interest. The Peptiderive server is available for free use at http://rosie.rosettacommons.org/peptiderive.