Cited by 483Open Access
Oregon Health & Science University
ORCID: 0000-0002-5247-510XPublishes on Immune cells in cancer, Cancer Cells and Metastasis, IL-33, ST2, and ILC Pathways. 26 papers and 2.1k citations.
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Deconstructing a perilous loop Cancer cells that give rise to solid tumors reside in a specialized microenvironment containing growth factors that support tumor growth and progression. The mechanisms by which tumor cells within this so-called “niche” attract and sustain these growth factors are poorly understood. Studying a mouse model of squamous cell carcinoma, Taniguchi et al. identified a signaling loop initiated by certain tumor cells within the niche that become more invasive on exposure to transforming growth factor β (TGF-β). They show that the tumor cells release the cytokine interleukin-33, which induces the differentiation of nearby myeloid cells into macrophages. These macrophages in turn release TGF-β, which feeds back to the tumor cells, promoting their malignant progression. Science this issue p. eaay1813