Cited by 467
Hyogo University
ORCID: 0000-0001-5907-9380Publishes on DNA Repair Mechanisms, Genomics and Chromatin Dynamics, Ubiquitin and proteasome pathways. 105 papers and 5.6k citations.
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The nucleotide exchange activity of RCC1, the only known nucleotide exchange factor for Ran, a Ras-like small guanosine triphosphatase, was required for microtubule aster formation with or without demembranated sperm in Xenopus egg extracts arrested in meiosis II. Consistently, in the RCC1-depleted egg extracts, Ran guanosine triphosphate (RanGTP), but not Ran guanosine diphosphate (RanGDP), induced self-organization of microtubule asters, and the process required the activity of dynein. Thus, Ran was shown to regulate formation of the microtubule network.