Ludmila Gavriliuc

Parodontitis (periodontitis) may be viewed as an infectious disease with a number of specific characteristics. Pathogens of the subgingival microbiota can interact with host tissues even without direct tissue penetration. Patients with mild or moderately severe periodontitis were treated with antihomotoxic therapy with Traumeel S, traditional therapy and using complex-therapy (Traumeel S + traditional therapy). Saliva as a biological liquid of the human organism may be a reflection of the metabolic state. Salivary indexes (parameters) may be very informative and are of clinico-diagnostical value in patients with oral tissues inflammation. The concentrations of creatinine, urea, proline and hydroxyproline, thiocyanate-ions (SCN-), chloride- ions (Cl-), and activity of alkaline phosphatase have been determined in the saliva of patients with periodontitis during special complex therapy. The results suggest that complex therapy with Traumeel S may be a more effective therapy than the traditional one in patients with periodontitis.

Activities of glutathione-dependent enzymes and glucose-6-phosphate dehydrogenase (GPDH) were studied in blood of the patients with lymphosarcoma (LS). The activity of glutathione reductase (GR), glutathione dehydroascorbate reductase (GDAR), gamma-glutamyltranspeptidase (GGT) and G6PDH in plasma, leucocytes, lymphocytes and erythrocytes of peripheral blood in 30 patients (42-56 years) with LS and in 20 healthy have been determined with spectrophotometric methods (Humalyzer 2000 DE). Leucocytes and lymphocytes were separated from blood using Boyum method. Spearmen method used for correlative analysis. The levels of enzymes activity and results of correlative analysis showed an imbalance of antioxidative system defense and metabolic disturbances in patients with LS. The strong functional interrelation was estimated only between GR and G6PDH in the patients' lymphocytes (r=+0,716; p<0.0005). Interrelation was found between the levels of activity of antioxidative enzymes and activity (stage) of pathologic process, this may be used as the additional biochemical test for differential diagnostics of LS and estimation of the cells proliferative activity.

Department of Pediatrics and Neonatology N1, State University of Medicine, Odessa, Ukraine, Biochemistry and Clinical Biochemistry Department, USMF “Nicolae Testemitanu”, Moldova