Lydie Trautmann

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

Nicolas Chomont, Mohamed El‐Far, Petronela Ancuța et al.|Nature Medicine|2009

Cited by 1.7kOpen Access

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

Lydie Trautmann, Loury Janbazian, Nicolas Chomont et al.|Nature Medicine|2006

Cited by 1.5k

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

Elias A. Said, Franck P. Dupuy, Lydie Trautmann et al.|Nature Medicine|2010

Cited by 475

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

The RV411 study group, Donn Colby, Lydie Trautmann et al.|Nature Medicine|2018

Cited by 332Open Access

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

Cari F. Kessing, Christopher C. Nixon, Chuan Li et al.|Cell Reports|2017

Cited by 257Open Access

T cells isolated from aviremic individuals. Combining dCA with ART accelerates HIV-1 suppression and prevents viral rebound after treatment interruption, even during strong cellular activation. We show that dCA mediates epigenetic silencing by increasing nucleosomal occupancy at Nucleosome-1, restricting RNAPII recruitment to the HIV-1 promoter. The efficacy of dCA was studied in the bone marrow-liver-thymus (BLT) mouse model of HIV latency and persistence. Adding dCA to ART-suppressed mice systemically reduces viral mRNA in tissues. Moreover, dCA significantly delays and reduces viral rebound levels upon treatment interruption. Altogether, this work demonstrates the potential of block-and-lock cure strategies.

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