I. Jonathan Amster

The irradiation of oxygen-free, face-centered-cubic C 60 films with visible or ultraviolet light phototransformed C 60 into a different solid phase. Results from laser desorption mass spectroscopy, scanning electron microscopy, Raman and infrared spectroscopy, optical absorption, and luminescence indicate that a photopolymerization of the fullerene molecules within the film occurred.

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTOligosaccharide Analysis by Mass Spectrometry: A Review of Recent DevelopmentsMuchena J. Kailemia†, L. Renee Ruhaak‡, Carlito B. Lebrilla‡, and I. Jonathan Amster*†View Author Information† Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States‡ Department of Chemistry, University of California at Davis, Davis, California 95616, United States*Phone: 706-542-2726. E-mail: [email protected]Cite this: Anal. Chem. 2014, 86, 1, 196–212Publication Date (Web):December 6, 2013Publication History Received6 December 2013Published online16 December 2013Published inissue 7 January 2014https://pubs.acs.org/doi/10.1021/ac403969nhttps://doi.org/10.1021/ac403969nreview-articleACS PublicationsCopyright © 2013 American Chemical SocietyRequest reuse permissionsArticle Views9142Altmetric-Citations307LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbohydrates,Chemical biology,Ions,Mass spectrometry,Oligosaccharides Get e-Alerts

The fundamental principles of Fourier transform mass spectrometry (FTMS) are presented. The motion of ions in a FTMS analyzer can be understood in terms of the magnetic and electric fields present in the FTMS analyzer cell. Ion motion is illustrated with the results of ion trajectory calculations under both collision-free conditions and at high pressure. Dipolar and quadrupolar excitation are described and compared. Practical considerations in obtaining ultra-high-mass resolution and accuracy are discussed. The FTMS experiment is a series of events (ionization excitation, detection) that occur in sequence. Pulse sequences for mass spectrometric and tandem mass spectrometric experiments are presented.

Although hundreds of heparan sulfate binding proteins have been identified and implicated in a myriad of physiological and pathological processes, very little information is known about the ligand requirements for binding and mediating biological activities by these proteins. This difficulty results from a lack of technology for establishing structure-activity relationships, which in turn is due to the structural complexity of natural heparan sulfate (HS) and difficulties of preparing well-defined HS oligosaccharides. To address this deficiency, we developed a modular approach for the parallel combinatorial synthesis of HS oligosaccharides that utilizes a relatively small number of selectively protected disaccharide building blocks, which can easily be converted into glycosyl donors and acceptors. The utility of the modular building blocks has been demonstrated by the preparation of a library of 12 oligosaccharides, which has been employed to probe the structural features of HS for inhibiting the protease, BACE-1. The complex variations in activity with structural changes support the view that important functional information is embedded in HS sequences. Furthermore, the most active derivative provides an attractive lead compound for the preparation of more potent compounds, which may find use as a therapeutic agent for Alzheimer's disease.