Marleen Van Troys

Mutations in human leucine-rich repeat kinase 2 (Lrrk2), a protein of yet unknown function, are linked to Parkinson's disease caused by degeneration of midbrain dopaminergic neurons. protein a a kinase by of in in of linked to to to in in of in dopaminergic midbrain in a of in of dopaminergic neurons. of are to of a of Mutations in human leucine-rich repeat kinase 2 (Lrrk2), a protein of yet unknown function, are linked to Parkinson's disease caused by degeneration of midbrain dopaminergic neurons. protein a a kinase by of in in of linked to to to in in of in dopaminergic midbrain in a of in of dopaminergic neurons. of are to of a of Parkinson's disease of in repeat kinase to by in human leucine-rich repeat kinase 2 of Parkinson's of are to to of are of Mutations in to a of of Mutations in of Parkinson's protein to of of Parkinson's leucine-rich repeat kinase 2 in of in to dopaminergic of of in midbrain dopaminergic of of Parkinson's in human a protein to protein Mutations in a of a of to a of a in by a kinase protein kinase kinase by in Parkinson's protein of of of to a kinase to of repeat kinase 2 a in of Parkinson's protein kinase in disease to kinase disease kinase Parkinson's in leucine-rich repeat kinase 2 kinase Parkinson's in kinase to to in to kinase to Parkinson's in kinase to of of repeat kinase 2 Parkinson's of of kinase of kinase are in by of by in of by of protein by by in by a of in by in a to in are of protein of protein of in of in of of of in to in neurons. a of a in of of of a of of a a a a a in of midbrain dopaminergic in of to in of midbrain dopaminergic by protein of by of a of of of by to of in of of in to of in 2 in a in a of a of in of in in protein by by by in a to in a in by protein kinase in of to by of by a of in to in 2 protein of by in protein by by of of by of protein in by by to protein to of in to by to a by a a of in in in a 2 by a to of in a of by a to in in a of to in of to a of in a a of a by protein of in to of by protein to protein to in of in of of protein to of by protein protein are in in 2 protein a of of a of are to to of protein by protein a to to by in in of of of a a of in a protein of to a of a of a of of of to by of are linked by by of in of protein of in of protein kinase to protein of to to of of of of a in in to a of to in of protein in by of to 2 2 to 2 in of by by to to of of of of by protein a of by of of in in to in of of in of in of midbrain dopaminergic in to of a of a in in in in by of in in by of of to a by a a of a of of to of of in of a by of a to of of to a to a of to in to a of to to to of a a by of by a are a of to of to of in of midbrain dopaminergic of of by of of of to of of by to are to of protein in of protein to in of a to of by by disease kinase to by in of by in in in in of are of of by by of by by to to of of of of of by in a of of in in a of by by to of to of by of to to in of of of by to of protein of in a of in in protein of of in by of to in of by to by in a to in in to to function, of of to of in to of are in a to of in of to of by of to of by are to by are to of by are to by are to of protein to by by of of of by of protein to of a to of by protein by protein of in in of of of protein a of a a a of to of in of in a by of of of of in a of by by of of of in in by are by to in protein in to by a of in in are are by in of a of of of a of in in a a of of by of by by of by of in of in of protein of in a of in of protein kinase of to by of a of in protein of in of to a in in by of in of of of of in in in of a of a of to in by in in of a of to by by by of a are in of in of in of protein of in of of in in of of in of to a of to in of in a in by a in in in of of to in in of of of a in a of of a are to of in 2 by to of a in in of of a a of of to in to of in of a in a of of in of in of a in in of to in of of a of in to of in a of of by to of a of to a of in of of in in a in of of in in of in of by to to a of of in a of to to a of in of by a in protein in a of in a of of in in of of in in in protein protein of dopaminergic by by in a of of of to in of of caused a in to of in a to of in to of neurons. in by of of in of of in a in of of neurons. of to a in of of of of of in a in of a of to of of neurons. of of to of to a in to of to a of a of of a to in in a in of of in to in in in of of a to of in in of of of neurons. of by of in in of to in Mutations in of Parkinson's of of protein of of protein are of protein repeat kinase 2 a in of Parkinson's of by of leucine-rich repeat kinase 2 leucine-rich repeat Mutations in Parkinson's disease to are linked to by of by linked to by are a of in of in in a in of by a of yet of in in a of are to of of of by of of a protein of by of of of of of in of of in in to in by of of by to are in of of to by of of a of by of in a are protein a of in in of to in a human of of a Parkinson's disease of Parkinson's disease kinase by of in of in in of of a Parkinson's disease of are of a protein of of in in of to of by of to in in of in of a a in to of of in to in to in of to of to in repeat kinase 2 to a of in in of by in protein of of of in are a of in of of in by to a of by degeneration of in in of in neurons. of in in a of in to of in by of by of of in of of of to of a of of of to to to a of in of by repeat kinase 2 of in a of of to in to to in of by of a of of of of in in of in by by in of by in in a of a by in in of a of of of are to to are unknown in a protein in a protein of protein in of of a in in protein to of by of to of to of in a in to kinase protein are to by by in kinase of in Parkinson's in in of of in of neurons. of of a Parkinson's disease of Parkinson's disease kinase a of in Parkinson's disease of in repeat kinase to by in human leucine-rich repeat kinase 2 of Parkinson's of are to to of are of Mutations in to a of of Mutations in of Parkinson's protein to of of Parkinson's leucine-rich repeat kinase 2 in of in to dopaminergic of of in midbrain dopaminergic of of Parkinson's in human Parkinson's disease of dopaminergic in protein leucine-rich repeat kinase 2 to by in a protein to protein Mutations in a of a of to a of a in by a kinase protein kinase kinase by in Parkinson's protein of of of to a kinase to of repeat kinase 2 a in of Parkinson's protein kinase in disease to kinase disease kinase Parkinson's in leucine-rich repeat kinase 2 kinase Parkinson's in kinase to to in to kinase to Parkinson's in kinase to of of repeat kinase 2 Parkinson's of of kinase of kinase are in by of by in of by of protein by by in by a of in by in a to in are of protein of protein of in of in of of of in to in neurons. a of a in of of of a of of a a a a a in of midbrain dopaminergic in of to in of midbrain dopaminergic by protein of by of a of of of by to of in of of in to of in 2 in a in a of a of in of in in protein by by by in a to in a in by protein kinase in of to by of by a of in to in 2 protein of by in protein by by of of by of protein in by by to protein to of in to by to a by a a of in in in a 2 by a to of in a of by a to in in a of to in of to a of in a a of a by protein of in to of by protein to protein to in of in of of protein to of by protein protein are in in 2 protein a of of a of are to to of protein by protein a to to by in in of of of a a of in a protein of to a of a of a of of of to by of are linked by by of in of protein of in of protein kinase to protein of to to of of of of a in in to a of to in of protein in by of to 2 2 to 2 in of by by to to of of of of by protein a of by of of in in to in of of in of in of midbrain dopaminergic in to of a of a in in in in by of in in by of of to a by a a of a of of to of of in of a by of a to of of to a to a of to in to a of to to to of a a by of by a are a of to of to of in of midbrain dopaminergic of of by of of of to of of by to are to of protein in of protein to in of a to of by by disease kinase to by in of by in in in in of are of of by by of by by to to of of of of of of of of a of of a a a a a in of midbrain dopaminergic in of of of a of of a a a a a in of midbrain dopaminergic in of to in of midbrain dopaminergic by protein of by of a of of of by to of in of of in to of to in of midbrain dopaminergic by protein of by of a of of of by to of in of of in to of in 2 in a in a of a of in of in in 2 in a in a of a of in of in in protein by by by in a to in a in by protein kinase in of to by of by a of in to in 2 protein of by in protein by by of of by of protein in by by to protein to of in to by protein by by by in a to in a in by protein kinase in of to by of by a of in to in 2 protein of by in protein by by of of by of protein in by by to protein to of in to by to a by a a of in in in a 2 by a to of in a of by a to in in a of to in of to a of in a a of a by protein of in to of by protein to protein to in of in of of protein to of by protein protein are in in 2 protein a of of to a by a a of in in in a 2 by a to of in a of by a to in in a of to in of to a of in a a of a by protein of in to of by protein to protein to in of in of of protein to of by protein protein are in in 2 protein a of of a of are to to of protein by protein a to to by in in of of of a a of in a protein of to a of a of a of of of to by of are linked by by a of are to to of protein by protein a to to by in in of of of a a of in a protein of to a of a of a of of of to by of are linked by by of in of protein of in of protein kinase to protein of to to of of of of a in in to a of to in of protein in by of to 2 2 to 2 in of by by to to of of of of by protein a of by of of in in to in in of protein of in of protein kinase to protein of to to of of of of a in in to a of to in of protein in by of to 2 2 to 2 in of by by to to of of of of by protein a of by of of in in to in of of in of in of midbrain dopaminergic in to of a of a in of of in of in of midbrain dopaminergic in to of a of a in in in in by of in in by in in in by of in in by of of to a by a a of a of of to of of in of a by of a to of of to a to a of to in to a of to to to of a a of to a by a a of a of of to of of in of a by of a to of of to a to a of to in to a of to to to of a a by of by a are a of to of by of by a are a of to of to of in of midbrain dopaminergic of of by of of of to of of by to are to to of in of midbrain dopaminergic of of by of of of to of of by to are to of protein in of protein to in of a to of by by disease kinase to by in of by in in in in of of protein in of protein to in of a to of by by disease kinase to by in of by in in in in of are of of by by of by by to to of of of of of are of of by by of by by to to of of of of of by in a of of in in a of by by to of to of by of to to in of of of by to of protein of in a of in in protein of of in by of to in of by to by in a to in in to to function, of of to of in to of are in a to of in of to of by of to of by are to by are to of protein to by by of of of by of protein to of a to of by protein by protein of in in of of of protein a of a a a of to of in of in a by of of of of in a of by by of of of in in by are by to in protein in to by a of in in are are by in of a of of of a of in in a a of of by of by by of by of in of in of protein of in a of in of protein kinase of to by of a of in protein of in of to a in in by of in of of of of in in in of a of a of to in by in in of a of to by by by of a are in of in of in of protein of in of of in in of of in of to a of to in of in a in by a in in in of of to in in of of of a in a of of a are to of in 2 by to of a in in of of a a of of to in to of in of a in a of of in of in of a in in of to in of of a of in to of in a of of by to of a of to a of in of of in in a in of of in in of in of by to to a of of in a of to to a of in of by a in protein in a of in a of of in in of of in in in protein protein of dopaminergic by by in a of of of to in of of caused a in to of in a to of in to of neurons. in by of of in of of in a in of of neurons. of to a in of of of of of in a in of a of to of of neurons. of of to of to a in to of to a of a of of a to in in a in of of in to in in in of of a to of in in of of of neurons. of by of in in by in a of of in in a of by by to of to of by of to to in of of of by to of protein of in a of in in protein of of in by of to in of by to by in a to in in to to function, of of to of in to of are in a to of in of to of by of to of by are to by are to of protein to by by of of in in of of of protein a of a a a of to of in of in a by of of of of in a of by by of of of in in by are by to in protein in to by a of in in are are by in of a of of of by to of protein of in a of in in protein of of in by of to in of by to by in a to in in to to function, of of to of in to of are in a to of in of to of by of to of protein to by by of of in in of of of protein a of a a a of to of in of in a by of of of of in a a of in in a a of of by of by by of by of in of in of protein of in a of in of protein kinase of to by of a of in protein of in of to a in in by of in of of of of in in in of a of a of of to in in of a of in in a a of of by of by by of by of in of in of protein of in a of in of protein kinase of to by of a of in protein of in of to a in in by of in of of of of in in in of a of a of of to in in of of of a in a of of a are to of in 2 by to of a in in of of a a of of to in to of in of a in a of of in of in of a in in of to in a in a of of a are to of in 2 by to of a in in of of a a of of to in to of in of a in a of of in of in of a in in of to in of in in a in of of in in of in of by to to a of of in a of to to a of in of by a in protein in a of in a of of in in of of dopaminergic by by in a of of of to in of of caused a in to of in a to of in to of neurons. in by of of in of of in a in of of neurons. of to a in of of of of of in a in of a of to of of neurons. of of to of to a in to of to a of a of of a to in in a in of of in to in in in of of a to of in in of of of neurons. of by of in in of of in in of in of by to to a of of in a of to to a of in of by a in protein in a of in a of of in in of of dopaminergic by by in a of of of to in of of caused a in to of in a to to of of neurons. of of to of to a in to of to a of a of of a to in in a in of of in to in in in of of a to of in in of of to in Mutations in of Parkinson's of of protein of of protein are of protein repeat kinase 2 a in of Parkinson's of by of leucine-rich repeat kinase 2 leucine-rich repeat Mutations in Parkinson's disease to are linked to by of by linked to by are a of in of in in a in of by a of yet of in in a of are to of of of by of of a protein of by of of of of of in of of in in to in by of of by to are in of of to by of of a of by of in a are protein a of in in of to in a human of of a Parkinson's disease of Parkinson's disease kinase by of in of in in of of a Parkinson's disease of are of a protein of of in in of to of by of to in in of in of a a in to of of in to in to in of to of to in repeat kinase 2 to a of in in of by in protein of of of in are a of in of of in by to a of by degeneration of in in of in neurons. of in in a of in to of in by of by of of in of of of to of a of of of to to to a of in of by repeat kinase 2 of in a of of to in to to in of by of a of of of of in in of in by by in of by in in a of a by in in of a of of of are to to are unknown in a protein in a protein of protein in of of a in in protein to of by of to of to of in a in to kinase protein are to by by in kinase of in Parkinson's in in of of in of neurons. of of a Parkinson's disease of Parkinson's disease kinase a of in of to in Mutations in of Parkinson's of of protein of of protein are of protein repeat kinase 2 a in of Parkinson's of by of leucine-rich repeat kinase 2 leucine-rich repeat Mutations in Parkinson's disease to are linked to by of by linked to by are a of in of in in a in of by a of yet of in in a of are to of of of by of of a protein of by of of of of of in of of in in to in by of of by to are in of of to by of of a of by of in a are protein a of in in of to in a human of of a Parkinson's disease of Parkinson's disease kinase by of in of in in of of a Parkinson's disease of are of a protein of of in in of to of by of to in in of in of a a in to of of in to in to in of to of to in repeat kinase 2 to a of in in of by in protein of of of in are a of in of of in by to a of by degeneration of in in of in neurons. of in in a of in to of in by of by of of in of of of to of a of of of to to to a of in of by repeat kinase 2 of in a of of to in to to in of by of a of of of of in in of in by by in of by in in a of a by in in of a of of of are to to are unknown in a protein in a protein of protein in of of a in in protein to of by of to of to of in a in to kinase protein are to by by in kinase of in Parkinson's in in of of in of neurons. of of a Parkinson's disease of Parkinson's disease kinase a of in