Cited by 4kOpen Access
Helmholtz Zentrum München
ORCID: 0000-0003-3169-479XPublishes on Adipose Tissue and Metabolism, Neurogenesis and neuroplasticity mechanisms, Pancreatic function and diabetes. 220 papers and 18.1k citations.
Add your photo, update your bio, and get notified when your ranking changes.
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.