Cited by 459
Crystallography is a basic tool for scientists in many diverse disciplines. This text offers a clear description of fundamentals and of modern applications. It supports curricula in crystallography at undergraduate level.
University of Verona
ORCID: 0000-0002-2067-0365Publishes on Enzyme Structure and Function, Drug Transport and Resistance Mechanisms, Protein Structure and Dynamics. 162 papers and 4.2k citations.
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Crystallography is a basic tool for scientists in many diverse disciplines. This text offers a clear description of fundamentals and of modern applications. It supports curricula in crystallography at undergraduate level.
The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site.