A. Palma

In this work, an Android application for measurement of nitrite concentration and pH determination in combination with a low-cost paper-based microfluidic device is presented. The application uses seven sensing areas, containing the corresponding immobilized reagents, to produce selective color changes when a sample solution is placed in the sampling area. Under controlled conditions of light, using the flash of the smartphone as a light source, the image captured with the built-in camera is processed using a customized algorithm for multidetection of the colored sensing areas. The developed image-processing allows reducing the influence of the light source and the positioning of the microfluidic device in the picture. Then, the H (hue) and S (saturation) coordinates of the HSV color space are extracted and related to pH and nitrite concentration, respectively. A complete characterization of the sensing elements has been carried out as well as a full description of the image analysis for detection. The results show good use of a mobile phone as an analytical instrument. For the pH, the resolution obtained is 0.04 units of pH, 0.09 of accuracy, and a mean squared error of 0.167. With regard to nitrite, 0.51% at 4.0 mg L(-1) of resolution and 0.52 mg L(-1) as the limit of detection was achieved.

This paper reports the development, evaluation and validation of DosiTag, a dosimetric platform based on Near Field Communication (NFC) technology. The designed system comprises two main parts: a passive NFC sensing tag as the dosimeter unit, which includes a commercial P-channel MOSFET transistor as radiation sensor; and an NFC-enabled smartphone running a custom-developed application as the reader unit. Additionally, a cloud service based on the messaging protocol Message Queue Telemetry Transport (MQTT) has been implemented using a broker/client architecture to allow the storage and classification of the patient’s data. The dosimeter tag was designed using commercial low-power integrated circuits (ICs) and it can operate without any external power supply or battery, being supplied by the smartphone through the radio frequency (RF) energy harvested from the NFC link. The radiation dose is measured through the increase of the DMOS transistor source voltage using the smartphone as the reader unit. Two tag prototypes have been characterized with a 6 MV photon beam and radiation doses up to 57 Gy and 42 Gy, respectively. The achieved average sensitivity is (4.37 ± 0.04) mV/Gy with a resolution of 2 cGy, which goes beyond the state-of-the-art of previous NFC dosimeters and places DosiTag as a low-cost promising electronic platform for dose control in radiotherapy treatments.