The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patientsMatthew Kennedy, Mark S. Forman, Larry Ereshefsky et al.|Science Translational Medicine|2016Cited by 416
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s DiseaseJack D. Scott, Andrew W. Stamford, Mark S. Forman et al.|Journal of Medicinal Chemistry|2016Cited by 165
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitorJared N. Cumming, Andrew W. Stamford, Ulrich Iserloh et al.|Bioorganic & Medicinal Chemistry Letters|2012Cited by 153
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase ActivityJack D. Scott, Michael W. Miller, John A. McCauley et al.|Journal of Medicinal Chemistry|2017Cited by 147
Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and ValidationZhaoning Zhu, John C. Hunter, Yu‐Sen Wang et al.|Journal of Medicinal Chemistry|2009Cited by 121