Leming Xiao

Connection of ship diesel power system with shore power can reduce the ship's energy consumption and realize environmental protection in the port. Difference in voltage, frequency and phase between the ship's power system and the shore power system generates the voltage difference envelope, and this paper, by testing of the lowest point of the envelope, controlled the switch to realize seamless and impulse current-free connection between the ship's power system and the shore power system. The envelope simulation model of frequency and phase variety is established to analyze the lowest point control performance of envelope. Besides, it established the synchronous-generator grid-connection operation equation under difference conditions of frequency difference and load changes. Under the classic load, when the frequency difference Δf between the ship's power system and the shore power system is a constant and the envelope reaches the lowest point, the switch is turned on, and then ratio control between the frequency difference and the power changes is established, the source of power supply is turned from the ship's power to shore power, and the load of the ship's power generator reduces to 10% Rated load - in this scenario, ideal synchronized control of the switch and load transfer is realized. Simulation and model tests confirmed the conclusion above. The simulation model is built to prove that the ship power generator's rotational inertia and frequency tracking coefficient have significant impact on the frequency, while difference adjustment characteristics have little impact. This paper solves the key problems in realizing seamless connection with the shore power and load transfer.

The increasing global prevalence of nonalcoholic fatty liver disease (NAFLD) starves for effective therapy, but no agent has been approved yet. We sought to evaluate the therapy of cefminox sodium (CMNX) on fatty accumulation in animal and cell models and explore the underlying mechanisms. The results revealed that CMNX reduced the gain of the liver and alleviated fatty accumulation both in high-fat high-sugar diet (HFHSD) mice's livers and WRL-68 cells. In HFHSD mice's livers and FFAs exposure hepatic cells, ACC1, SREBP-1c, and CYP2E1 were enhanced expression, which were reversed by CMNX treatment. In addition, PPARγ, PPARα, PCK1, and ACSL4 expressions were increased in CMNX-treated WRL-68 cells. These findings suggest that CMNX improves fatty accumulation in HFHSD mice/hepatic cells by restraining fatty acid synthesis and facilitating fatty acid oxidation.

In the prokaryotic kingdom, protein phosphorylation serves as one of the most important posttranslational modifications (PTMs) and is involved in orchestrating a broad spectrum of biological processes. Here, we report an updated online server named the group-based prediction system for prokaryotic phosphorylation language model (GPS-pPLM), used for predicting phosphorylation sites (p-sites) in prokaryotes. For model training, two deep learning methods, a transformer and a deep neural network, were employed, and a total of 10 sequence features and contextual features were integrated. Using 44,839 nonredundant p-sites in 16,041 proteins from 95 prokaryotes, two general models for the prediction of O-phosphorylation and N-phosphorylation were first pretrained and then fine-tuned to construct 6 predictors specific for each phosphorylatable residue type as well as 134 species-specific predictors. Compared with other existing tools, the GPS-pPLM exhibits higher accuracy in predicting prokaryotic O-phosphorylation p-sites. Protein sequences in FASTA format or UniProt accession numbers can be submitted by users, and the predicted results are displayed in tabular form. In addition, we annotate the predicted p-sites with knowledge from 22 public resources, including experimental evidence, 3D structures, and disorder tendencies. The online service of the GPS-pPLM is freely accessible for academic research.

The backflow region length in sudden-reduction oil tube is not only closely associated with its energy loss, but is also closely related to the partition between orifice plate and plug. In this paper, the characteristics of backflow region length in sudden-reduction oil tube are researched. The results illustrated that backflow region length decreases with the increase in the contraction ratio. Moreover, when Reynolds number is more than 105, Reynolds number has little impact on backflow region length. Empirical expression about backflow region length in sudden-reduction oil tube is also discussed in this paper.