Paras N. Prasad

ADVERTISEMENT RETURN TO ISSUEReviewNEXTUpconversion Nanoparticles: Design, Nanochemistry, and Applications in TheranosticsGuanying Chen*†‡, Hailong Qiu†‡, Paras N. Prasad*‡§, and Xiaoyuan Chen*∥View Author Information† School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China‡ Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, State University of New York, Buffalo, New York 14260, United States§ Department of Chemistry, Korea University, Seoul 136-701, Korea∥ Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892-2281, United States*E-mail: [email protected]*E-mail: [email protected]*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 10, 5161–5214Publication Date (Web):March 10, 2014Publication History Received5 August 2013Published online10 March 2014Published inissue 28 May 2014https://doi.org/10.1021/cr400425hCopyright © 2014 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views75082Altmetric-Citations1907LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (60 MB) Get e-AlertsSUBJECTS:Biological imaging,Ions,Lanthanides,Luminescence,Nanoparticles Get e-Alerts

Basis and Formulation of Nonlinear Optics Origin of Microscopic Nonlinearity in Organic Systems Bulk Nonlinear Optical Susceptiblity Second Order Nonlinear Optical Processes Measurement Techniques for Second-Order Nonlinear Optical Effects A Survey of Second Order Nonlinear Optical Materials Third-Order Nonlinear Optical Processes Measurement Techniques for Third-Order Effects A Survey of Third-Order Nonlinear Optical Materials Nonlinear Optics in Optical Waveguides and Fibers Device Conepts Issues and Future Directions.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiphoton Absorbing Materials: Molecular Designs, Characterizations, and ApplicationsGuang S. He, Loon-Seng Tan, Qingdong Zheng, and Paras N. PrasadView Author Information Institute for Lasers, Photonics and Biophotonics, State University of New York at Buffalo, New York 14260-3000, and Polymer Branch, Materials & Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Ohio 45433-7750 Cite this: Chem. Rev. 2008, 108, 4, 1245–1330Publication Date (Web):March 25, 2008Publication History Received4 January 2007Published online25 March 2008Published inissue 1 April 2008https://pubs.acs.org/doi/10.1021/cr050054xhttps://doi.org/10.1021/cr050054xresearch-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views18635Altmetric-Citations1880LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Dyes and pigments,Fluorescence,Lasers,Quantum mechanics Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and TherapyGuanying Chen‡†, Indrajit Roy†§, Chunhui Yang*‡, and Paras N. Prasad*†View Author Information† Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, United States‡ School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China§ Department of Chemistry, University of Delhi, Delhi 110007, India*E-mail: [email protected]*E-mail: [email protected]Cite this: Chem. Rev. 2016, 116, 5, 2826–2885Publication Date (Web):January 22, 2016Publication History Received12 March 2015Published online22 January 2016Published inissue 9 March 2016https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00148https://doi.org/10.1021/acs.chemrev.5b00148review-articleACS PublicationsCopyright © 2016 American Chemical SocietyRequest reuse permissionsArticle Views28825Altmetric-Citations1183LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biological imaging,Fluorescence,Metal oxide nanoparticles,Nanoparticles,Quantum dots Get e-Alerts

A novel nanoparticle-based drug carrier for photodynamic therapy is reported which can provide stable aqueous dispersion of hydrophobic photosensitizers, yet preserve the key step of photogeneration of singlet oxygen, necessary for photodynamic action. A multidisciplinary approach is utilized which involves (i) nanochemistry in micellar cavity to produce these carriers, (ii) spectroscopy to confirm singlet oxygen production, and (iii) in vitro studies using tumor cells to investigate drug-carrier uptake and destruction of cancer cells by photodynamic action. Ultrafine organically modified silica-based nanoparticles (diameter approximately 30 nm), entrapping water-insoluble photosensitizing anticancer drug 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide, have been synthesized in the nonpolar core of micelles by hydrolysis of triethoxyvinylsilane. The resulting drug-doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. The entrapped drug is more fluorescent in aqueous medium than the free drug, permitting use of fluorescence bioimaging studies. Irradiation of the photosensitizing drug entrapped in nanoparticles with light of suitable wavelength results in efficient generation of singlet oxygen, which is made possible by the inherent porosity of the nanoparticles. In vitro studies have demonstrated the active uptake of drug-doped nanoparticles into the cytosol of tumor cells. Significant damage to such impregnated tumor cells was observed upon irradiation with light of wavelength 650 nm. Thus, the potential of using ceramic-based nanoparticles as drug carriers for photodynamic therapy has been demonstrated.