Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>Holly K. Koblish, Anna C. Maroney, Pierre Raboisson et al.|Molecular Cancer Therapeutics|2006Cited by 164
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug designDaniel J. Parks, Tianbao Lu, Louis V. LaFrance et al.|Bioorganic & Medicinal Chemistry Letters|2006Cited by 76
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activityKristi Leonard, Tianbao Lu, Juan Marugán et al.|Bioorganic & Medicinal Chemistry Letters|2006Cited by 60
Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonistsPierre Raboisson, Maxwell D. Cummings, Juan Marugán et al.|Bioorganic & Medicinal Chemistry Letters|2005Cited by 50
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonistsJuan Marugán, Tianbao Lu, Kristi Leonard et al.|Bioorganic & Medicinal Chemistry Letters|2006Cited by 34