Paul A. Cohen

Serious study of nineteenth- and twentieth-century Chinese history did not really get under way in the United States until after World War II. Since then, scholarly publication has proliferated and a genuine professional field-by far the largest and most active in the West-has taken shape. Now, for the first time, we have a critical, book-length analysis of this development, written by an insider and structured around the leading conceptual approaches that have informed American scholarship in the postwar decades. In Paul A. Cohen's view, the supreme problem for American students of Chinese history, particularly in its post-Western impact phase, has been one of ethnocentric distortion. The first two chapters of the book explore this problem in connection with the two approaches that were most influential in American scholarship of the 1950s and 1960s-the impact-response and modernization (tradition-modernity) approaches. In chapter three, Dr. Cohen argues that a third major approach, the imperialism approach, although emerging in the late 1960s as a critique of the two earlier approaches, has been no less Western-centric in its basic presuppositions. The final chapter traces the increasing efforts of American historians to move beyond the Western-centric paradigms of the past toward a more China-centered approach to recent Chinese history-an approach that strives empathetically to reconstruct the Chinese past as the Chinese themselves experienced it rather than in terms of an imported sense of historical problem. Dr. Cohen concludes with a discussion of some of the implications of this new approach for our understanding of recent Chinese history. Students of Chinese history, Sino-American relations, and the evolution of American historical scholarship on non-Western societies will welcome this perceptive and thought-provoking book.

Cardio-oncology has organically developed as a new discipline within cardiovascular medicine as a result of the cardiac and vascular adverse sequelae of the major advances in cancer treatment. Patients with cancer and cancer survivors are at increased risk of vascular disease for a number of reasons. First, many new cancer therapies, including several targeted therapies, are associated with vascular and metabolic complications. Second, cancer itself serves as a risk factor for vascular disease, especially by increasing the risk for thromboembolic events. Finally, recent data suggest that common modifiable and genetic risk factors predispose to both malignancies and cardiovascular disease. Vascular complications in patients with cancer represent a new challenge for the clinician and a new frontier for research and investigation. Indeed, vascular sequelae of novel targeted therapies may provide insights into vascular signaling in humans. Clinically, emerging challenges are best addressed by a multidisciplinary approach in which cardiovascular medicine specialists and vascular biologists work closely with oncologists in the care of patients with cancer and cancer survivors. This novel approach realizes the goal of providing superior care through the creation of cardio-oncology consultative services and the training of a new generation of cardiovascular specialists with a broad understanding of cancer treatments.

Historical reconstruction is in constant tension with two other more pervasive and influential ways of "knowing" the past - experience and myth. In this long-awaited book, Paul Cohen uses the Boxer uprising of 1898-1900 - a major antiforeign explosion and watershed event in Chinese history - as a vehicle for the skillful illumination of these tensions

We have analyzed the amino acid sequences situated around the putative proteolytic cleavage sites in twenty different biosynthetic precursors of peptide hormones by processing enzymes. The prediction of the probability for forming secondary structures around the basic amino acids, constituting the cleavage sites, was made using the modified method of Chou and Fasman. The results indicate that the processing sequences which are cleaved in vivo, are in all cases located inside regions with high beta-turn formation probability or else immediately adjacent to these structures. The beta-turn forming region at the cleavage locus, is flanked on both sides by amino acid sequences with a high probability for forming highly ordered structures, either beta-sheet or alpha-helix. These conformational features are not found in precursors around dibasic pairs, i.e. putative cleavage loci, but which are not cleaved in vivo and appear to be conserved. We hypothesize that beta-turns including the basic amino acids doublets, flanked by highly ordered secondary structures (either beta-sheet or alpha-helix) may constitute a minimal requirement for the recognition by the endoproteases involved in the processing of these precursors.