Cited by 1.6kOpen Access
University of Massachusetts Chan Medical School
ORCID: 0000-0002-9520-3382Publishes on Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Pancreatic function and diabetes. 78 papers and 10.6k citations.
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Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.