Jing Zhao

Andrographis paniculata (A. paniculata) is a medicinal plant traditionally used as anti-inflammation and anti-bacteria herb. Andrographolide, the major active component of A. paniculata, exhibits diverse pharmacological activities, including anti-inflammation, anti-cancer, anti-obesity, anti-diabetes, and other activities. In this article, we comprehensively review the therapeutic potential of A. paniculata and andrographolide focusing on the mechanisms of action and clinical application. We systemically discuss the structure-activity relationship of andrographolide and derivatives. Despite the various pharmacological activities and formula of A. paniculata and andrographolide, we propose further development of more structural derivatives of andrographolide with reduced toxicity and increased therapeutic efficacy is still needed for the clinical application of this ancient mighty herb and its major component.

Polymer-based conductive hydrogels have the synergistic advantages of high conductivity and tissue-like properties, making them promising candidates for the construction of flexible electronic devices. However, conductive hydrogel materials can easily absorb microorganisms due to their high water content. To address the problem that conductive hydrogels are susceptible to infection by external pathogens when monitoring wounds and when used in implanted organs, tannic acid-borax (TA-B) complexes are introduced into classical dual network polyacrylamide/agarose (PAM/Agar) hydrogels to form PAM/Agar/TA-B hydrogel conductors. These hydrogels are antibacterial and have good mechanical properties, light transmission, electrical conductivity, and adhesion. TA-B increases the compressive stress of the PAM/Agar/TA-B hydrogel by 58.14% compared to a PAM/Agar hydrogel. The PAM/Agar/TA-B hydrogel can be used as an electronic conductor for electronic skin and wearable sensors. Outstanding biocompatibility allows the hydrogel to be used as a monitoring device at wounds to monitor heartbeat, skin wounds, and internal tissue status in real time. In summary, an antibacterial strain sensing matrix that is safe for human health monitoring is developed.

Abstract Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum ( F. nucleatum ) in colorectal carcinoma tissue; many studies have indicated that F. nucleatum is closely related to the colorectal carcinogenesis. In this review, we provide the latest information to reveal the related molecular mechanisms. The known virulence factors of F. nucleatum promote adhesion to intestinal epithelial cells via FadA and Fap2. Besides, Fap2 also binds to immune cells causing immunosuppression. Furthermore, F. nucleatum recruits tumor‐infiltrating immune cells, thus yielding a pro‐inflammatory microenvironment, which promotes colorectal neoplasia progression. F. nucleatum was also found to potentiate CRC development through toll‐like receptor 2 (TLR2)/toll‐like receptor 4 (TLR4) signaling and microRNA (miRNA)‐21 expression. In addition, F. nucleatum increases CRC recurrence along with chemoresistance by mediating a molecular network of miRNA‐18a*, miRNA‐4802, and autophagy components. Moreover, viable F. nucleatum was detected in mouse xenografts of human primary colorectal adenocarcinomas through successive passages. These findings indicated that an increased number of F. nucleatum in the tissues is a biomarker for the diagnosis and prognosis of CRC, and the underlying molecular mechanism can probably provide a potential intervention treatment strategy for patients with F. nucleatum ‐associated CRC.