Ning Xia

An ideal pair: Various substituted aryl halides react under mild conditions with nitrogen heterocycles in the presence of catalytic amounts of [Fe(acac)3] (acac=acetylacetonate) and copper salts to give the corresponding cross-coupling products in high yields (see scheme). This cheap and environmentally friendly co-catalyst system is the first example of cooperative Fe/Cu catalysis in this type of NC bond formation. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603173_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Phasing up to matters: The use of aqueous ammonia in a biphasic system with a copper catalyst and diketone supporting ligands allows the catalytic amination of both activated and unactivated aryl and heteroaryl iodides and bromides under very mild conditions (see scheme; R=electron-donating or -withdrawing group; acac=acetylacetonate). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Cheap and cheerful: The direct copper-catalyzed hydroxylation of activated and unactivated aryl iodides or bromides has been achieved using metal hydroxide salts (MOH). Selective hydroxylation in a H2O/co-solvent system avoids formation of the related biaryl ether by-product and the low cost of the copper catalytic system makes this method very competitive. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

The first general entry into copper-catalyzed arylation of phenols from aryl chlorides is the principal outcome of the study presented in this article. The use of the 2,2,6,6-tetramethyl-3,5-heptanedione (1) as ligand is the key to the success of this reaction. An additional finding of this study, touched upon only briefly here, is the 1/Fe-catalyzed arylation of phenols from aryl iodides (R=a donating or an electron-withdrawing group). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2111/2008/z800436_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.