Shabnam Mombini, Javad Mohammadnejad, Behnaz Bakhshandeh et al.|International Journal of Biological Macromolecules|2019
Cited by 184
Tarbiat Modares University
ORCID: 0000-0002-0223-9838Publishes on Tissue Engineering and Regenerative Medicine, Electrospun Nanofibers in Biomedical Applications, Pluripotent Stem Cells Research. 27 papers and 783 citations.
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A novel biodegradable electroactive polyurethane containing aniline pentamer (AP) was blended with polycaprolactone (PCL). The prepared blend (PB) and PCL were further fabricated in to scaffolds using a mixture of poly(ethylene glycol) and salt particles in a double porogen particulate leaching and compression molding methodology. Scaffolds held open and interconnected pores having pore size ranging from several μm to 150 µm. PB scaffolds had compression modulus and strength of 4.1 and 1.3 MPa, respectively. The conductivity of the scaffold was measured as 10(-5) ± 0.09 S .cm(-1) and preserved for at least 100 h post fabrication. Scaffolds supported neonatal cardiomyocytes adhesion and growth with PB showing more extensive effect on the expression of the cardiac genes involved in muscle contraction and relaxation (troponin-T) and cytoskeleton alignment (actinin-4). Our results highlight the potential of incorporation of AP as an electroactive moiety for induction of cardiomyocyte proliferation and repair of damaged heart tissue.