Tarja Laitinen

Susceptibility to asthma depends on variation at an unknown number of genetic loci. To identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. One of these coded for an orphan G protein-coupled receptor named GPRA (G protein-coupled receptor for asthma susceptibility), which showed distinct distribution of protein isoforms between bronchial biopsies from healthy and asthmatic individuals. In three cohorts from Finland and Canada, single nucleotide polymorphism-tagged haplotypes associated with high serum immunoglobulin E or asthma. The murine ortholog of GPRA was up-regulated in a mouse model of ovalbumin-induced inflammation. Together, these data implicate GPRA in the pathogenesis of atopy and asthma.

BACKGROUND: In clinical practice, patients whose airway disease shares features of both asthma and chronic obstructive pulmonary disease (COPD) remain poorly recognized. MATERIAL AND METHODS: The study population consisted of 1546 patients with a diagnosis of asthma or COPD or both. Based on patient-reported outcomes and retrospective medical record data, the study population was divided into three groups: ( 1 ) asthma only, ( 2 ) COPD only, and ( 3 ) both asthma and COPD (overlap syndrome group). We evaluated patient characteristics associated with health-related quality of life (HRQoL). RESULTS: In many respects, the overlap group fell between the asthma and COPD groups. In the overlap group, however, HRQoL was the poorest of all. In the logistic regression model, with the asthma group as the reference, both the overlap and the COPD group showed higher risk for low HRQoL [odd ratio (OR): 1.9; 95% confidence interval (CI): 1.2-3.2; and OR: 1.8, 95% CI: 1.0-3.2; respectively]. In addition, female gender, obesity, duration of disease, disability pension, and coexisting cardiovascular disease were associated with low HRQoL across the study population. CONCLUSIONS: Patients with overlapping asthma and COPD differed from those patients with asthma or COPD only. Overlap syndrome was associated with low HRQoL.

PURPOSE: To define normal values for the Pelli-Robson contrast sensitivity test in different age groups. SETTING: University Eye Clinic of Kuopio, Kuopio, Finland. METHODS: Contrast sensitivity was measured with the Pelli-Robson contrast sensitivity test in 87 persons (60 women and 27 men) with a mean age of 34.5 years +/- 20.8 (SD) (range 6 to 75 years). Results were studied by age group (years): 6 to 9, 10 to 19, 20 to 29, 30 to 39, 40 to 49, 50 to 59, and 60 and older. Of 163 eyes, both were healthy in 76 persons and 1 was healthy in 11. Study participants consisted of members of the staff of the Kuopio University Hospital Eye Clinic, medical students at the Kuopio University, and patients of the Strabismus and General Ophthalmology Units of the Eye Clinic and their accompanying persons. Two test distances were used: 1 m and 3 m. Eyes were tested individually; thereafter, the test was done binocularly. RESULTS: There were significant differences in logarithmic contrast sensitivity values among the age groups except on the test of the left eye at 1 m. The P values for the right eye at 1 m and 3 m, left eye at 1 m and 3 m, and both eyes at 1 m and 3 m were 0.003, 0.002, 0.19, 0.043, 0.037, and 0.003, respectively. The mean test results in 1 eye varied from 1.68 in the 60 year and older group to 1.84 in the 20 to 29 and 30 to 39 year groups. Binocularly, the variation was from 1.73 in the 40 year group to 1.99 in the 30 year group. CONCLUSIONS: The Pelli-Robson contrast sensitivity test is a quick and reliable method in a clinical setting. Normal values of the test can be of help in evaluating cataract patients or patients having refractive surgery.