Ming-Chun Huang

We present a compact mobile phone platform for rapid, quantitative biomolecular detection. This system consists of an embedded circuit for signal processing and data analysis, and disposable microfluidic chips for fluidic handling and biosensing. Capillary flow is employed for sample loading, processing, and pumping to enhance operational portability and simplicity. Graphical step-by-step instructions displayed on the phone assists the operator through the detection process. After the completion of each measurement, the results are displayed on the screen for immediate assessment and the data is automatically saved to the phone's memory for future analysis and transmission. Validation of this device was carried out by detecting Plasmodium falciparum histidine-rich protein 2 (PfHRP2), an important biomarker for malaria, with a lower limit of detection of 16 ng mL(-1) in human serum. The simple detection process can be carried out with two loading steps and takes 15 min to complete each measurement. Due to its compact size and high performance, this device offers immense potential as a widely accessible, point-of-care diagnostic platform, especially in remote and rural areas. In addition to its impact on global healthcare, this technology is relevant to other important applications including food safety, environmental monitoring and biosecurity.

Sitting posture analysis is widely applied in many daily applications in biomedical, education, and health care domains. It is interesting to monitor sitting postures in an economic and comfortable manner. Accordingly, we present a textile-based sensing system, called Smart Cushion, which analyzes the sitting posture of human being accurately and non-invasively. First, we introduce the electrical textile sensor and its electrical characteristics, such as offset, scaling, crosstalk, and rotation. Second, we present the design and implementation of the Smart Cushion system. Several effective techniques have been proposed to improve the recognition rate of sitting postures, including sensor calibration, data representation, and dynamic time warping-based classification. Last, our experimental results show that the recognition rate of our Smart Cushion system is in excess of 85.9%.

Detecting human activity independent of intensity is essential in many applications, primarily in calculating metabolic equivalent rates and extracting human context awareness. Many classifiers that train on an activity at a subset of intensity levels fail to recognize the same activity at other intensity levels. This demonstrates weakness in the underlying classification method. Training a classifier for an activity at every intensity level is also not practical. In this paper, we tackle a novel intensity-independent activity recognition problem where the class labels exhibit large variability, the data are of high dimensionality, and clustering algorithms are necessary. We propose a new robust stochastic approximation framework for enhanced classification of such data. Experiments are reported using two clustering techniques, K-Means and Gaussian Mixture Models. The stochastic approximation algorithm consistently outperforms other well-known classification schemes which validate the use of our proposed clustered data representation. We verify the motivation of our framework in two applications that benefit from intensity-independent activity recognition. The first application shows how our framework can be used to enhance energy expenditure calculations. The second application is a novel exergaming environment aimed at using games to reward physical activity performed throughout the day, to encourage a healthy lifestyle.

Gait analysis is an important medical diagnostic process and has many applications in rehabilitation, therapy and exercise training. However, standard human gait analysis has to be performed in a specific gait lab and operated by a medical professional. This traditional method increases the examination cost and decreases the accuracy of the natural gait model. In this paper, we present a novel portable system, called Smart Insole, to address the current issues. Smart Insole integrates low cost sensors and computes important gait features. In this way, patients or users can wear Smart Insole for gait analysis in daily life instead of participating in gait lab experiments for hours. With our proposed portable sensing system and effective feature extraction algorithm, the Smart Insole system enables precise gait analysis. Furthermore, taking advantage of the affordability and mobility of Smart Insole, pervasive gait analysis can be extended to many potential applications such as fall prevention, life behavior analysis and networked wireless health systems.

Sleep plays a pivotal role in the quality of life, and sleep posture is related to many medical conditions such as sleep apnea. In this paper, we design a dense pressure-sensitive bedsheet for sleep posture monitoring. In contrast to existing techniques, our bedsheet system offers a completely unobtrusive method using comfortable textile sensors. Based on high-resolution pressure distributions from the bedsheet, we develop a novel framework for pressure image analysis to monitor sleep postures, including a set of geometrical features for sleep posture characterization and three sparse classifiers for posture recognition. We run a pilot study and evaluate the performance of our methods with 14 subjects to analyze 6 common postures. The experimental results show that our proposed method enables reliable sleep posture recognition and offers better overall performance than state-of-the-art methods, achieving up to 83.0% precision and 83.2% recall on average.