Gunma University
Publishes on HIV Research and Treatment, T-cell and Retrovirus Studies, HIV/AIDS drug development and treatment. 3 papers and 127 citations.
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The fidelity of DNA synthesis by reverse transcriptases from human immunodeficiency virus and other retroviruses was compared by measuring the rates of misincorporation of dCMP in the place of TMP in cell-free DNA synthesis with polyadenylic acid as the template. The fidelity of human immunodeficiency virus reverse transcriptase was found to be about one-third of that of the reverse transcriptases of other retroviruses.
The infectivity of human immunodeficiency virus (HIV) was inhibited by heparin, though de-N-sulfated heparin and heparin pretreated with protamine sulfate were hardly inhibitory. There was a correlation between the anticoagulant activities and anti-HIV activities of heparin-related compounds.
The reverse transcriptase (RT) activity of a lysate of human immunodeficiency virus type 1 (HIV) was almost completely inactivated by incubation at 56 degrees C for 20-30 min. The heat-inactivation of RT in the virus lysate or purified RT was partially inhibited in the presence of some human sera or plasma containing antibodies against HIV. The IgG fraction purified from the seropositive sera was responsible for stabilization of RT upon heat inactivation. This is a new assay system for detection of antibodies against RT.