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Leonardo Serra

Universidad del Desarrollo

ORCID: 0000-0001-9752-1934

Publishes on Obstructive Sleep Apnea Research, Sleep and related disorders, Sleep and Wakefulness Research. 22 papers and 4k citations.

22Publications
4kTotal Citations

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Cataplexy features in childhood narcolepsy
Leonardo Serra, Pasquale Montagna, Emmanuel Mignot et al.|Movement Disorders|2008
Cited by 163Open Access

Cataplexy, the hallmark of narcolepsy, has been well characterized in adults but not in children. This study systematically used structured clinical assessments and video-recordings (49 episodes in eight cases) to evaluate cataplexy in 23 patients diagnosed before the age of 18 years. Forty-three percent of patients had falls as part of their attacks. During cataplexy knees, head, and jaw were the most frequently compromised body segments; eyelids, arms, and trunk being less commonly involved. More rarely, blurred vision, slurred speech, irregular breathing, or a sudden loss of smiling mimics were reported. One-third of the sample presented with a previously unrecognized description of cataplexy that we coined "cataplectic facies," consisting of a state of semipermanent eyelid and jaw weakness, on which partial or complete cataplectic attacks were superimposed. The usual triggering emotions, such as laughter, joking, or anger, were not always present, especially when close to an abrupt onset, hampering diagnosis. Video-recordings of cataplectic attacks may be useful to document the attack, allowing a comparison with archived presentations.

Endodermal sinus tumor arising in the endometrium.
Cited by 47

A case of primary endodermal sinus tumor (EST) of the endometrium in a 28-year-old woman is described. EST has been reported to arise in several extragonadal sites, but to the authors' knowledge this is the first documented instance of origin in the endometrium. The histologic study is verified by the detection of alpha-fetoprotein in the tumor by an immunoperoxidase-peroxidase-antiperoxidase technique reported here. Displaced germinal cells, abnormal ovum, and residual fetal tissues are considered as possible origins of the neoplasia.