Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer’s DiseaseRobert Martone, J. Steven Jacobsen, Scott C. Mayer et al.|Journal of Pharmacology and Experimental Therapeutics|2009Cited by 157
Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascadeJ. Steven Jacobsen, Menelas N. Pangalos, Thomas A. Comery et al.|Proceedings of the National Academy of Sciences|2008Cited by 141
Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s DiseaseScott C. Mayer, J. Steven Jacobsen, Anthony F. Kreft et al.|Journal of Medicinal Chemistry|2008Cited by 111
P2‐481: Small molecule BACE‐1 inhibitors are potent, selective and orally activeMichael S. Malamas, Jonathan Bard, Jim Erdei et al.|Alzheimer s & Dementia|2008Cited by 2
CCDC 767715: Experimental Crystal Structure DeterminationScott C. Mayer, J. Steven Jacobsen, Anthony F. Kreft et al.|The Cambridge Structural Database|2010Cited by 0