ApoE Promotes the Proteolytic Degradation of AβQingguang Jiang, Gary E. Landreth, C.Y. Daniel Lee et al.|Neuron|2008Cited by 869
The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's diseaseDavid Riddell, Jan Jacobsen, Hua Zhou et al.|Molecular and Cellular Neuroscience|2007Cited by 248
Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer’s DiseaseRobert Martone, J. Steven Jacobsen, Hua Zhou et al.|Journal of Pharmacology and Experimental Therapeutics|2009Cited by 157
Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascadeJ. Steven Jacobsen, Menelas N. Pangalos, Thomas A. Comery et al.|Proceedings of the National Academy of Sciences|2008Cited by 141
Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s DiseaseScott C. Mayer, J. Steven Jacobsen, Anthony F. Kreft et al.|Journal of Medicinal Chemistry|2008Cited by 111