Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac MyosinArjun S. Adhikari, Kathleen M. Ruppel, Chao Liu et al.|Cell Reports|2016Cited by 94
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activityArjun S. Adhikari, Kathleen M. Ruppel, Saswata S. Sarkar et al.|Nature Communications|2019Cited by 90
Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed stateAlison Schroer Vander Roest, Daniel Bernstein, Kathleen M. Ruppel et al.|Proceedings of the National Academy of Sciences|2021Cited by 81
Incomplete-penetrant hypertrophic cardiomyopathy <i>MYH7</i> G256E mutation causes hypercontractility and elevated mitochondrial respirationSoah Lee, Daniel Bernstein, Kathleen M. Ruppel et al.|Proceedings of the National Academy of Sciences|2024Cited by 13
Hypertrophic cardiomyopathy mutations at the folded-back sequestered β-cardiac myosin S1-S2 and S1-S1 interfaces release sequestered heads and increase myosin enzymatic activityArjun S. Adhikari, Kathleen M. Ruppel, Saswata S. Sarkar et al.|bioRxiv (Cold Spring Harbor Laboratory)|2019Cited by 6