Ashar Ahmed

BACKGROUND: Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. METHODS: In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. FINDINGS: Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87-1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98-1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87-1·03; p=0·24). INTERPRETATION: In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. FUNDING: UK Research and Innovation (Medical Research Council) and National Institute of Health Research.

Behavior of right turning vehicles in the context of safety is characterized by their use of turning indicators and compliance with the stop rule. They are influence by the width of the carriageway and the variation in volume on the major road with respect to the traffic moving in the near and far side direction. Other factors affecting the behavior are the speed and spacing between vehicles moving on the major road. Lack of adequate past knowledge on the effect of geometric variation in terms of road width and directional variation in volume on the safety of unsignalized intersections have provided the motivation for this study. This paper focuses on the many factors that affect the behavior of right-turning vehicles resulting into conflicts. A brief account of the unique indigenous maneuver termed as the “Weaving Merging Right Turn” (WMRT) is provided and its effectiveness with respect to conventional right turn is evaluated. Data of 39,016 vehicles collected on 10 sites between January and June 2014 was analyzed. Multiple accidents were observed only on sites which had near side traffic volume greater than far side traffic volume. This result remains consistent with sites having single as well as multiple lanes per direction on the major roads. The number of conflicts for vehicles performing the WMRT was 2.5 times less as compared to the conventional right turn. Moreover WMRT was found to be the maneuver of choice for right turning motorcyclists with 60% of them opting for it over the conventional right turn on intersections having major road width less than 9 m. None of the motorcyclists, which were involved in a traffic conflict, were observed to use their turning indicator. Moreover none of the motorcyclists, which experienced a traffic conflict, were found to comply with the stopping rule at sites with major road width less than 9 m. On sites with major road width greater than 9 m, 45% of motorcyclists, involved in a traffic conflict, complied with the stopping rule as compared to 79% by vehicles other than motorcycles.

Wireless sensor networks (WSN) have recently gained popularity among graduate and undergraduate student researchers due to the availability of sensor nodes at low cost. This low cost along with miniaturization of nodes has made it possible to employ WSNs in many applications. To test the performance of WSN in the field we need some infrastructure which monitor the status of each node and also serve as a link for reprogramming. Such infrastructure is termed as deployment support by the researchers. In this paper we first introduce wireless sensor network and then review two deployment support infrastructures one wired and other wireless implemented by two different teams. The merits and limitations of both are discussed in the end

Accident data could be of various types. Count data being one of them. Effective accident analysis requires classification of count data with respect to geometric and control parameters. This paper focuses on the analysis of the effects of road width, land use, lane marking and traffic control on safety of unsignalized intersections. Intersection lying in non-urban areas with single line marking and no control on minor road were found to be the most vulnerable. The results are discussed and the recommendations are provided.