Cited by 1.6kOpen Access
University of Antwerp
ORCID: 0000-0002-2162-0933Publishes on Hereditary Neurological Disorders, Neurological diseases and metabolism, Genetic Neurodegenerative Diseases. 343 papers and 24.8k citations.
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Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.