Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for Three-Dimensional Organotypic Cultures
Yihua Loo(Institute of Bioengineering and Nanotechnology), Anupama Lakshmanan(Institute of Bioengineering and Nanotechnology), Ming Ni(Institute of Bioengineering and Nanotechnology), Lai Ling Toh(Institute of Bioengineering and Nanotechnology), Shi Wang(National University Hospital), Charlotte A. E. Hauser(Institute of Bioengineering and Nanotechnology)
Cited by 195
Abstract
Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells and tissues. We report the first peptide bioinks-lysine-containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional hydrogels with unprecedented stiffness of up to 40 kPa. These biocompatible scaffolds support the three-dimensional culture of human stem cells and differentiation of primary cells into organotypic (gastrointestinal and skin) structures for high-throughput screening, diagnosis, and tissue engineering.
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