PEG-associated efficacy loss in lipid nanoparticles persists across formulation modifications for mRNA delivery
Mariah L. Arral(Tufts University), Kathryn A. Whitehead(Carnegie Mellon University), Namit Chaudhary(Scripps Research Institute), Alexandra N. Newby(Carnegie Mellon University), Katherine C. Fein(Carnegie Mellon University), Saigopalakrishna S. Yerneni(Carnegie Mellon University), Jilian R. Melamed(Kaiser Permanente), Daria M. Strelkova Petersen(Carnegie Mellon University), Samuel T. LoPresti(Carnegie Mellon University)
Cited by 0
Related Papers
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
|Nature Reviews Drug Discovery|2021|1.5k
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs
|Journal of Controlled Release|2022|270
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
|Science Advances|2023|196
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing <i>In Vivo</i>
|Nano Letters|2020|144
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d
|Nature Biomedical Engineering|2024|107