PD-1 remodels SHP2 dynamics and drives the non-catalytic inhibition of T cell activation

Panyu Fei(Zhejiang University), Wei Chen(Second Affiliated Hospital of Zhejiang University), Yu Zhang(Institute of Biophysics), Peng Jiao(Zhejiang Chinese Medical University), Peng Wu(Second Affiliated Hospital of Zhejiang University), Michael L. Dustin(Chinese Academy of Medical Sciences & Peking Union Medical College), Jizhong Lou(Institute of Biophysics), Lu Chen(Sir Run Run Shaw Hospital), Jie Gao(Second Affiliated Hospital of Zhejiang University), Hui Chen(Institute of Biophysics), Chun Zhou(Guangdong Pharmaceutical University), Lina Chen(Sir Run Run Shaw Hospital), Salvatore Valvo(University of Oxford)
bioRxiv (Cold Spring Harbor Laboratory)
May 22, 2026
Cited by 0


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