IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors

Khadija Banu(Yale University), Samuel W. Brady(St. Jude Children's Research Hospital), Matthew M. Wielgosz(St. Jude Children's Research Hospital), Laurence C. Cheung(The Kids Research Institute Australia), Robert J. Mobley(St. Jude Children's Research Hospital), Kelly R. Barnett(St. Jude Children's Research Hospital), Vishwajeeth Pagala(St. Jude Children's Research Hospital), Robert E. Throm(St. Jude Children's Research Hospital), X X(St. Jude Children's Research Hospital), W Wang(St. Jude Children's Research Hospital), Matthew Bauler(St. Jude Children's Research Hospital), Mohammad Aslam Khan(St. Jude Children's Research Hospital), Daniel Savic(St. Jude Children's Research Hospital), Sihan Li(St. Jude Children's Research Hospital), Christopher Wincek(St. Jude Children's Research Hospital), Morgan Reynolds-Gagliano(St. Jude Children's Research Hospital), Daniel Putnam(St. Jude Children's Research Hospital), Xiaofei Wang(St. Jude Children's Research Hospital), Kiran Kodali(St. Jude Children's Research Hospital), Rishi S. Kotecha(The Kids Research Institute Australia), Shondra M Pruett-Miller(St. Jude Children's Research Hospital), Anthony A. High(St. Jude Children's Research Hospital)

Science Advances

April 29, 2026

Cited by 2

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