Genetic Determinants of Multiple Sclerosis Susceptibility in People From Diverse Ancestral Backgrounds
Benjamin M. Jacobs(Queen Mary University of London), Luisa Schalk(Queen Mary University of London), Emily Tregaskis-Daniels(Queen Mary University of London), Antonio Scalfari(NIHR Imperial Biomedical Research Centre), Ashwini Nandoskar(Imperial College Healthcare NHS Trust), Angie Dunne(Leeds Teaching Hospitals NHS Trust), Bruno Gran(Nottingham University Hospitals NHS Trust), Charles A. Mein(Queen Mary University of London), Charlotte Sellers(Queen Mary University of London), Cord E. Spilker(Bradford Teaching Hospitals NHS Foundation Trust), David Rog(Northern Health and Social Care Trust), Elisa Visentin(Barking, Havering And Redbridge University Hospitals NHS Trust), Elizabeth Lindsey Bezzina(Lewisham and Greenwich NHS Trust), Emeka Uzochukwu(Cardiff University), Emma Tallantyre(University Hospital of Wales), Eva Wozniak(Queen Mary University of London), Eve Sacre(Leeds Teaching Hospitals NHS Trust), Ghaniah Hassan‐Smith(University Hospitals Birmingham NHS Foundation Trust), Helen L. Ford(Leeds Teaching Hospitals NHS Trust), Jade Harris(Northern Health and Social Care Trust), Joan Bradley(Imperial College Healthcare NHS Trust), Joshua Robert Breedon(Queen Mary University of London), Judith Brooke(Northern Health and Social Care Trust), Karim L. Kreft(Nottingham University Hospitals NHS Trust), Katila George(Queen Mary University of London), Maria Martha Papachatzaki(Torbay and South Devon NHS Foundation Trust), Martin O'Malley(Leeds Teaching Hospitals NHS Trust), Michelle Peter(Queen Mary University of London), Miriam Mattoscio(Barking, Havering And Redbridge University Hospitals NHS Trust), Laura Azzopardi(Barking, Havering And Redbridge University Hospitals NHS Trust), Renato Oliveira(Barking, Havering And Redbridge University Hospitals NHS Trust), Neisha Rhule(Lewisham and Greenwich NHS Trust), Nikos Evangelou(Nottingham University Hospitals NHS Trust), Nimisha Vinod(Northern Health and Social Care Trust), Outi Quinn(Bradford Teaching Hospitals NHS Foundation Trust), Fhateha Ali(Bradford Teaching Hospitals NHS Foundation Trust), Ramya Shamji(Barking, Havering And Redbridge University Hospitals NHS Trust), Rashmi Kaimal(Queen Mary University of London), Rebecca L. Boulton(Nottingham University Hospitals NHS Trust), Riffat Tanveer(Lancashire Teaching Hospitals NHS Foundation Trust), Katherine Tuite-Dalton(Swansea University), Rod Middleton(Swansea University), Roxanne Murray(Queen Mary University of London), Ruth Bellfield(Bradford Teaching Hospitals NHS Foundation Trust), Sadid Hoque(Queen Mary University of London), Shakeelah Patel(Lancashire Teaching Hospitals NHS Foundation Trust), Sonia Raj(Lancashire Teaching Hospitals NHS Foundation Trust), Stephanie Gumus(Torbay and South Devon NHS Foundation Trust), Stephanie Mitchell(Bradford Teaching Hospitals NHS Foundation Trust), Stephen J. Sawcer(University of Cambridge), Tarunya Arun(University Hospitals Coventry and Warwickshire NHS Trust), Tatiana Pogreban(Barking, Havering And Redbridge University Hospitals NHS Trust), Terri-Louise Brown(Queen Mary University of London), Thamanna Begum(Queen Mary University of London), Veronica Antoine(Northern Health and Social Care Trust), Waqar Rashid(St George’s University Hospitals NHS Foundation Trust), Grace Fawehinmi(Barking, Havering And Redbridge University Hospitals NHS Trust), Claire Reidy(Leeds Teaching Hospitals NHS Trust), Shanaz Begum(Leeds Teaching Hospitals NHS Trust), Shannon A. Bernard Healey(Queen Mary University of London), Harriet Cummins(University Hospitals Coventry and Warwickshire NHS Trust), Kelly Westwood(University Hospitals Coventry and Warwickshire NHS Trust), Deborah Spencer(Northern Health and Social Care Trust), Shegufta Farooq(Bradford Teaching Hospitals NHS Foundation Trust), Katharine Harding(Aneurin Bevan University Health Board), Sarah Williams(Aneurin Bevan University Health Board), G. Radford(Aneurin Bevan University Health Board), Selina White(Nottingham University Hospitals NHS Trust), Nathan Alldred-Douglas(Leeds Teaching Hospitals NHS Trust), Linford Fernandes(Leeds Teaching Hospitals NHS Trust), Adil Harroud(Montreal Neurological Institute and Hospital), Jacob L McCauley(University of Miami), Ashley Beecham(Wake Forest University), Nicolas Vince(Inserm), Nayane dos Santos Brito Silva(Inserm), Huw R. Morris(Queen Mary University of London), E. Silber(Barking, Havering And Redbridge University Hospitals NHS Trust), Gavin Giovannoni(Queen Mary University of London), Alastair J. Noyce(Queen Mary University of London), Dobson Ruth(Queen Mary University of London)
Cited by 1Open Access
Abstract
BACKGROUND AND OBJECTIVES: The genetic basis of multiple sclerosis (MS) susceptibility has been studied extensively in European (EUR) ancestry populations. The aim of our study was to determine the genetic architecture of MS susceptibility in people of South Asian (SAS) and African (AFR) genetic ancestral backgrounds. METHODS: We recruited and genotyped a cohort of ancestrally diverse people with MS (pwMS) from across the United Kingdom. Cases were combined with controls from the UK Biobank (UKB). After genetic ancestry inference, we performed within-ancestry case-control genetic association studies of MS susceptibility, exploring single nucleotide variants and imputed classical human leukocyte antigen alleles. RESULTS: allele in the SAS cohort, which has not been previously described. DISCUSSION: The genetic architecture of MS susceptibility shows strong concordance across ancestral groups suggesting shared disease mechanisms. Larger studies in diverse populations are likely to enhance our understanding of how genetic variation contributes to MS susceptibility in people of all ancestral backgrounds.
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